114779-46-3

Basic information

• Product Name: [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester
• Synonyms: [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester
• CAS NO: 114779-46-3
• Molecular Weight: 543.665
• Mol File: 114779-46-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester(114779-46-3)
• EPA Substance Registry System: [1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl]carbamic acid,9H-fluoren-9-ylmethyl ester(114779-46-3)

Safety Data

• Hazardous Substances Data: 114779-46-3(Hazardous Substances Data)

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 153-91-3 DL-α-methyltryptophan 
• 114779-80-5 N-(Fmoc)-DL-α-methyltryptophal 
• 64-04-0 phenethylamine 

Downstream Products

• 114779-47-4 (2-phenylethyl)amine 
• 129397-60-0 N-n-butyloxycarbonyl-DL-α-methyl tryptophanyl-2-phenethylamide 
• 129397-62-2 N-benzyloxycarbonyl-DL-α-methyl tryptophanyl-2-phenethylamide 
• 129397-63-3 [2-(1H-Indol-3-yl)-1-methyl-1-phenethylcarbamoyl-ethyl]-carbamic acid phenyl ester 
• 129397-59-7 N-n-propyloxycarbonyl-DL-α-methyl tryptophanyl-2-phenylethylamide 
• 114779-49-6 N-t-butylaminocarbonyl-DL-α-methyl tryptophanyl-2-phenethylamide 
• 129397-64-4 N-tert-butylacetyl-DL-α-methyl tryptophanyl-2-phenylethylamide 
• 129397-61-1 N-isopropyloxycarbonyl-DL-α-methyl tryptophanyl-2-phenethylamide 
• 129397-58-6 N-ethyloxycarbonyl-DL-α-methyl tryptophanyl-2-phenethylamide 
• 129397-57-5 N-methyloxycarbonyl-DL-α-methyl tryptophanyl-2-phenethylamide 

Relevant articles and documents

N-SUBSTITUTED CYCLOALKYL AND POLYCYCLOALKYL ALPHA-SUBSTITUTED TRP-PHE- AND PHENETHYLAMINE DERIVATIVES

Novel unnatural dipeptoids of α-substituted Trp-Phe derivatives useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further the compounds are antianxiety agents, antiulcer agents, antidepressant agents, and are agents useful for preventing the withdrawal response produced by chronic treatment or use followed by chronic treatment followed by withdrawal from nicotine, diazepam, alcohol, cocaine, caffeine, or opiods. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare pharmaceutical and diagnostic compositions.

α-Methyl tryptophanylphenylalanines and their arylethylamine 'dipeptoid' analogues of the tetrapeptide cholecystokinin (30-33)

A series of N-alkyl carbamate blocked α-Me-Trp-Phe and α-Me-Trp-phenethylamides has been identified as 'dipeptoid' analogues of CCK-4 (CCK 30-33). These compounds have micromolar affinity for the type-B central CCK receptor, some of which increase the fir