1147869-54-2

Basic information

• Product Name: ethyl (2E)-3-(acetylamino)-2-(4-fluorophenyl)-3-phenylacrylate
• CAS NO: 1147869-54-2
• Molecular Weight: 327.355
• Mol File: 1147869-54-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl (2E)-3-(acetylamino)-2-(4-fluorophenyl)-3-phenylacrylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2E)-3-(acetylamino)-2-(4-fluorophenyl)-3-phenylacrylate(1147869-54-2)
• EPA Substance Registry System: ethyl (2E)-3-(acetylamino)-2-(4-fluorophenyl)-3-phenylacrylate(1147869-54-2)

Safety Data

• Hazardous Substances Data: 1147869-54-2(Hazardous Substances Data)

Upstream product

• 1147869-34-8 ethyl 2-diazo-3-hydroxy-3-(4-fluorophenyl)-3-phenylpropanoate 

Downstream Products

• 1575-95-7 N-acetylbenzamide 
• 1813-94-1 ethyl 4-fluorobenzoylformate 

Relevant articles and documents

BF3 · Et2O-induced decomposition of ethyl 2-diazo-3-hydroxy-3,3-diarylpropanoates in acetonitrile: A novel approach to 2,3-diaryl β-enamino ester derivatives

The BF3·Et2O-induced decomposition of ethyl 2-diazo-3-hydroxy-3,3-diarylpropanoates, prepared by the addition of a series of benzophenones to ethyl diazo(lithio)acetate, is reported and studied. By using acetonitrile as a solvent, the corresponding N-acyl β-enamino ester derivatives are obtained in good yields and with a diverse regioselectivity as the result of 1,2-aryl migration in the vinyl cation intermediates. The factors that govern the migratory aptitude as well as the mechanistic aspects of the reaction are discussed.