114800-58-7

Basic information

• Product Name: 4H-Pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine,6-(2-chlorophenyl)-7,8,9,10-tetrahydro-1-methyl-
• Synonyms: NHPTT
• CAS NO: 114800-58-7
• Molecular Formula: C18H16 Cl N5 S
• Molecular Weight: 369.878
• Mol File: 114800-58-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 631.7±65.0 °C(Predicted)
• Density: 1.59±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 4H-Pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine,6-(2-chlorophenyl)-7,8,9,10-tetrahydro-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine,6-(2-chlorophenyl)-7,8,9,10-tetrahydro-1-methyl-(114800-58-7)
• EPA Substance Registry System: 4H-Pyrido[4',3':4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine,6-(2-chlorophenyl)-7,8,9,10-tetrahydro-1-methyl-(114800-58-7)

Safety Data

• Hazardous Substances Data: 114800-58-7(Hazardous Substances Data)

Downstream Products

• 130310-65-5 C₂₂H₁₉ClN₆OS 
• 132418-41-8 6-(2-chlorophenyl)-7,10-dihydro-1-methyl-N-(2-trifluoromethylphenyl)-4H-pyrido[4',3';4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-9(8H)-carbothioamide 
• 252754-65-7 6-(2-chlorophenyl)-7,10-dihydro-1-methyl-N-(2-trifluoromethylbenzyl)-4H-pyrido[4',3';4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-9(8H)-carbothioamide 
• 252754-66-8 phenyl ester of 6-(2-chlorophenyl)-7,10-dihydro-4H-pyrido[4',3';4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-9(8H)-carboxylic acid 
• 132418-52-1 6-(2-chlorophenyl)-7,10-dihydro-1-methyl-N-benzyl-4H-pyrido[4',3';4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-9(8H)-carboxamide 
• 252754-64-6 6-(2-chlorophenyl)-7,10-dihydro-1-methyl-N-(2-trifluoromethylphenyl)-4H-pyrido[4',3';4,5]thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-9(8H)-carboxamide 
• 132418-36-1 BN 50730 
• 130310-44-0 3-(3-butynyloxycarbonyl)-6-(2-chlorophenyl)-8,11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine 
• 130310-47-3 C₂₇H₂₈ClN₅O₂S 
• 140167-29-9 C₂₅H₂₄ClN₅O₂S 
• 130311-20-5 C₂₆H₂₁ClFN₅OS 
• 140167-28-8 C₂₆H₂₂ClN₅O₂S 
• 130310-38-2 6-(2-chlorophenyl)-11-methyl-3-(2-propynyl)-2,3,4,5-tetrahydro-8H-pyrido<4',3':4,5>thieno<3,2-f><1,2,4>triazolo<4,3-a><1,4>diazepine 
• 140167-26-6 C₂₉H₂₄ClN₅O₂S 

Relevant articles and documents

Use of diazepines for preparing medicines for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors

The invention concerns the use of pyrido-thieno-triazolo-diazepins for preparing a medicine for treating pathological conditions or diseases involving one of the growth hormone release inhibiting factor receptors. The invention also concerns novel pyrido-

Determination of the kinetic constants of the reversible opening of a triazolo-1,4thienodiazepine in water at different pH values: A striking example of the determination of intimately intricate kinetic and equilibrium constants

Apparent kinetic constants of the reversible opening of a triazolo-l,4-thienodiazepine were determined by UV-spectrophotometry and by polarography in water at several pH values assuming as a hypothesis a stationary state for the carbinolamine intermediate. Both the apparent kinetic constants, ￡fand k, exhibited a maximum for the values H0 = -0.25 and pH = 6.07. A possible determination of the elementary kinetic constants of the several acidobasic species which may be involved in the opening and closing process according to the pH and pKa values was studied and is discussed. The results are consistent with the hypothesis that both the opening of the diazepine cycle and the closing of the opened form proceed through a mechanism suggesting that the protonated form of the carbinolamine function of the intermediate is involved. 1999 lohn Wiley & Sons. Inc.