1148009-61-3Relevant academic research and scientific papers
Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists
Sakamoto, Toshihiro,Moriya, Minoru,Haga, Yuji,Takahashi, Toshiyuki,Shibata, Takunobu,Okamoto, Osamu,Nonoshita, Katsumasa,Kitazawa, Hidefumi,Hidaka, Masayasu,Gomori, Akira,Iwaasa, Hisashi,Ishihara, Akane,Kanatani, Akio,Fukami, Takehiro,Gao, Ying-Duo,MacNeil, Douglas J.,Yang, Lihu
scheme or table, p. 1564 - 1568 (2009/12/07)
A series of spiroindoline-3,4′-piperidine derivatives were synthesized and evaluated for their binding affinities and antagonistic activities at Y5 receptors. Potent Y5 antagonists were tested for their oral bioavailabilities and brain penetration in rats
