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178261-41-1

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178261-41-1 Usage

General Description

1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] is a chemical compound with a spirocyclic structure that contains a sulfone functional group. It is a type of spiro compound, where two cyclic parts are connected through a single atom. 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] has been studied for its potential pharmacological properties, including its activity as a dopamine D3 receptor antagonist and its potential use in the treatment of neurological and psychiatric disorders. It is also being investigated for its potential role in the development of new drug therapies. The spirocyclic structure of 1-(methylsulfonyl)spiro[indoline-3,4'-piperidine] makes it an interesting target for synthetic chemistry and medicinal chemistry research.

Check Digit Verification of cas no

The CAS Registry Mumber 178261-41-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,8,2,6 and 1 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 178261-41:
(8*1)+(7*7)+(6*8)+(5*2)+(4*6)+(3*1)+(2*4)+(1*1)=151
151 % 10 = 1
So 178261-41-1 is a valid CAS Registry Number.

178261-41-1Relevant articles and documents

Domino Aryne Annulation via a Nucleophilic-Ene Process

Xu, Hai,He, Jia,Shi, Jiarong,Tan, Liang,Qiu, Dachuan,Luo, Xiaohua,Li, Yang

, p. 3555 - 3559 (2018/03/21)

1,2-Benzdiyne equivalents possess the unique property that they can react with two arynophiles through iteratively generated 1,2- and 2,3-aryne intermediates. Upon rational modification on the second leaving group of these aryne precursors, a domino aryne annulation approach was developed through a nucleophilic-ene reaction sequence. Various benzo-fused N-heterocyclic frameworks were achievable under transition metal-free conditions with a broad substrate scope.

A facile synthesis of the spiroindoline-based growth hormone secretagogue, MK-677

Qi, Xian Liang,Yang, Er Qun,Zhang, Jun Tao,Wang, Tao,Cao, Xiao Ping

, p. 661 - 664 (2012/07/03)

A facile and improved route for the synthesis of the orally active spiroindoline-based growth hormone secretagogue, MK-677 was described. The key step adopted the Fischer indole/reduction strategy. The preparation of the key intermediates N-protected piperidine carboxaldehyde 5 and the N-Boc-O-benzyl-d-serine (2) are also optimized.

CYCLOPROPYL DERIVATIVES AS NK3 RECEPTOR ANTAGONISTS

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Page/Page column 61, (2010/02/10)

The present invention relates to cyclopropyl derivatives of formula (I) and salt thereof. These compounds are NK3 receptor antagonists and may therefore be useful for treatment of diseases where the NK3 receptor is implicated, e.g. psychotic disorders.

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