1148050-25-2Relevant academic research and scientific papers
Decarboxylative Borylation of Stabilized and Activated Carbon Radicals
Li, Xiaojuan,Ni, Shengyang,Pan, Yi,Wang, Yi,Zhang, Qiang,Zhang, Weigang
supporting information, p. 21875 - 21879 (2020/10/02)
Redox-active esters (RAEs) as active radical precursors have been extensively studied for C?B bond formations. However, the analogous transformations of stabilized radicals from the corresponding acid precursors remain challenging owing to the strong preference towards single-electron oxidation to the stable carbocations. This work describes a general strategy for rapid access to various aliphatic and aromatic boronic esters by mild photoinduced decarboxylative borylation. Both aryl and alkyl radicals could be generated from the leaving group-assisted N-hydroxybenzimidoyl chloride esters, even α-CF3 substituted substrates could be activated for further elaboration.
Synthesis of α-trifluoromethyl-phenethylamines from α-trifluoromethyl β-aryl enamines and β-chloro-β- (trifluoromethyl)styrenes
Muzalevskiy, Vasiliy M.,Shastin, Aleksey V.,Balenkova, Elizabeth S.,Haufe, Günter,Nenajdenko, Valentine G.
experimental part, p. 1247 - 1253 (2011/11/12)
A novel synthetic approach towards α-trifluoromethyl-phenethylamines was elaborated by reduction of the electron deficient β-aryl-α- trifluoromethyl enamines and imines with sodium cyanoborohydride in the presence of trifluoroacetic acid. The starting imines were prepared by the reaction of primary amines with β-aryl-α-trifluoromethyl enamines or β-chloro-β-(trifluoromethyl)styrenes.
Synthesis of trifluoromethyl alcohols from tert-butoxy-β-(trifluoromethyl)styrenes and trifluoromethylbenzyl ketones under the conditions of the Leuckart-Wallach reaction
Muzalevskiy, Vasiliy M.,Nenajdenko, Valentine G.,Shastin, Aleksey V.,Balenkova, Elizabeth S.,Haufe, Günter
scheme or table, p. 1052 - 1055 (2009/04/04)
A novel pathway towards trifluoromethylalcohols by an unexpected reaction of tert-butoxy-β-(trifluoromethyl)styrenes or corresponding trifluoromethylbenzyl ketones under the conditions of the Leuckart-Wallach reaction was elaborated.
