114809-62-0Relevant articles and documents
Method for synthesizing azanol
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Paragraph 0157; 0183; 0190, (2016/10/08)
The invention relates to a hydroxylamine synthesis method. The hydroxylamine synthesis method comprises the following steps: (A) enabling alcohol to react with alkyl sulfonyl halide in the presence of an acid-binding agent to obtain sulphonate; (B) enabling the obtained sulphonate in the step (A) to react with N-hydroxycyclodiimide in the presence of alkali to generate alkylate of the N-hydroxycyclodiimide; and (C) enabling the alkylate obtained in the step (B) to react with an aminolysis reagent or a hydrazinolysis reagent to obtain the hydroxylamine. The method is high in yield and suitable for large-scale industrial hydroxylamine synthesis.
N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS
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Page 20, (2008/06/13)
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SYNTHESIS OF 9-(3-HYDROXYPROPOXY)GUANINE, A NOVEL ANTIVIRAL ACYCLONUCLEOSIDE
Harnden, M. R.,Parkin, A.,Wyatt, P. G.
, p. 701 - 704 (2007/10/02)
Synthetic approaches to 9-(3-hydroxypropoxy)guanine (2) involving the intermediacy of either a 1-alkoxyimidazole (7) or a 4-alkoxyaminopyrimidine (13) are described.This 9-alkoxyguanine (2) has potent and selective anti-herpesvirus activity and is the first reported member of a new series of antiviral acyclonucleosides.