114809-45-9

Basic information

• Product Name: 1H-Isoindole-1,3(2H)-dione, 2-[3-(phenylmethoxy)propoxy]-
• CAS NO: 114809-45-9
• Molecular Formula: C18H17NO4
• Molecular Weight: 311.337
• Mol File: 114809-45-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1H-Isoindole-1,3(2H)-dione, 2-[3-(phenylmethoxy)propoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Isoindole-1,3(2H)-dione, 2-[3-(phenylmethoxy)propoxy]-(114809-45-9)
• EPA Substance Registry System: 1H-Isoindole-1,3(2H)-dione, 2-[3-(phenylmethoxy)propoxy]-(114809-45-9)

Safety Data

• Hazardous Substances Data: 114809-45-9(Hazardous Substances Data)

Upstream product

• 524-38-9 N-hydroxyphthalimide 
• 4799-68-2 3-benzyloxypropan-1-ol 

Downstream Products

• 114809-46-0 O-(3-Benzyloxy-propyl)-hydroxylamine; hydrochloride 
• 114809-62-0 3-(benzyloxy)propoxyamine 
• 867168-92-1 2-amino-3-hydroxy-propionaldehyde O-(3-benzyloxy-propyl)-oxime 
• 116477-29-3 C₁₃H₂₀N₂O₂ 
• 114778-21-1 5-Amino-1-(3-benzyloxy-propoxy)-1H-imidazole-4-carboxylic acid amide 
• 114778-20-0 C₁₄H₁₈N₄O₃ 
• 114778-89-1 9-(3-benzyloxypropoxy)guanine 
• 116477-32-8 9(3-Benzyloxyprop-1-oxy)-6-chloro-2-formamidopurine 
• 116477-31-7 N-[4-(3-Benzyloxy-propoxyamino)-6-chloro-5-formylamino-pyrimidin-2-yl]-formamide 

Relevant articles and documents

Method for synthesizing azanol

The invention relates to a hydroxylamine synthesis method. The hydroxylamine synthesis method comprises the following steps: (A) enabling alcohol to react with alkyl sulfonyl halide in the presence of an acid-binding agent to obtain sulphonate; (B) enabling the obtained sulphonate in the step (A) to react with N-hydroxycyclodiimide in the presence of alkali to generate alkylate of the N-hydroxycyclodiimide; and (C) enabling the alkylate obtained in the step (B) to react with an aminolysis reagent or a hydrazinolysis reagent to obtain the hydroxylamine. The method is high in yield and suitable for large-scale industrial hydroxylamine synthesis.

Synthesis and antiviral activity of 9-alkoxypurines. 1. 9-(3-Hydroxypropoxy)- and 9-[3-hydroxy-2-(hydroxymethyl)propoxy]purines

Reaction of hydroxyl-protected derivatives of hydroxyalkoxyamines (3a,b,c) with either 4,6-dichloro-2,5-diformamidopyrimidine (5) or 4,6-dichloro-5-formamidopyrimidine (31) and subsequent cyclization of the resultant 6-(alkoxyamino)pyrimidines (6, 17, 32, 35) by heating with diethoxymethyl acetate afforded 9-alkoxy-6-chloropurines (7, 18, 33, 36), which were converted subsequently to 9-(3-hydroxypropoxy)- and 9-[3-hydroxy-2-(hydroxymethyl)propoxy] derivatives of guanine, 2-amino-6-chloropurine, 2-amino-6-alkoxypurines, 2-aminopurine, 2,6-diaminopurine, adenine, hypoxanthine, and 6-methoxypurine (8, 12, 13, 19-21, 23-26, 34, 37-39). Carboxylic acid esters (9-11, 14-16, 27-29) and a cyclic phosphate derivative (22) of the 9-(hydroxyalkoxy)guanines (8, 21) and 2-amino-9-(hydroxyalkoxy)purines (13, 26) were also prepared. The guanine derivatives (8, 21) showed potent and selective activity against herpes simplex virus types 1 and 2 and varicella zoster virus in cell cultures and 8 is more active than acyclovir. Although without significant antiviral activity in cell cultures, the 2-aminopurines (13, 14-16, 26-29) and 2-amino-6-alkoxypurines (12, 23-25) are well absorbed after oral administration to mice and are converted efficiently to the antiviral guanine derivatives (8, 21) in vivo.