1148156-72-2Relevant articles and documents
Talipexole variations as novel bitopic dopamine D2 and D3receptor ligands
Stank, Lars,Frank, Annika,Hagenow, Stefanie,Stark, Holger
, p. 1926 - 1929 (2019)
We linked 2-aminothiazoloazepane scaffolds with phenylpiperazine pharmacophores to generate bitopic dopamine receptor ligands. Highest D2R/D3R binding affinities up to pKi values of 7.74 were observed for compounds containing a 1-(2,3-dichlorophenyl)piperazinoyl moiety, maintaining affinity with deaminated 5,6,7,8-tetrahydro-4H-thiazoloazepine derivatives.