1148158-15-9

Basic information

• Product Name: N-hydroxy-4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxamide
• Synonyms: N-hydroxy-4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxamide
• CAS NO: 1148158-15-9
• Molecular Weight: 297.337
• Mol File: 1148158-15-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-hydroxy-4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-hydroxy-4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxamide(1148158-15-9)
• EPA Substance Registry System: N-hydroxy-4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxamide(1148158-15-9)

Safety Data

• Hazardous Substances Data: 1148158-15-9(Hazardous Substances Data)

Upstream product

• 228413-59-0 ethyl 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxylate 
• 630409-69-7 ethyl 2-(pyridin-4-yl)-4-[(trifluoromethyl)sulfonyloxy]-1,3-thiazole-5-carboxylate 
• 2196-13-6 pyridine-4-carbothioamide 
• 190271-73-9 ethyl 4-hydroxy-2-(4-pyridyl)-1,3-thiazole-5-carboxylate 
• 1225963-57-4 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid 

Relevant articles and documents

Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors

The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in the identification of a potent, selective Cdc7 inhibitor that decreased phosphorylation of the direct substrate MCM2 in vitro and in vivo, and inhibited DNA synthesis and cell viability in vitro.