1225963-57-4

Basic information

• Product Name: 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid
• Synonyms: 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid
• CAS NO: 1225963-57-4
• Molecular Weight: 282.323
• Mol File: 1225963-57-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid(1225963-57-4)
• EPA Substance Registry System: 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxylic acid(1225963-57-4)

Safety Data

• Hazardous Substances Data: 1225963-57-4(Hazardous Substances Data)

Upstream product

• 228413-59-0 ethyl 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxylate 
• 630409-69-7 ethyl 2-(pyridin-4-yl)-4-[(trifluoromethyl)sulfonyloxy]-1,3-thiazole-5-carboxylate 
• 2196-13-6 pyridine-4-carbothioamide 
• 190271-73-9 ethyl 4-hydroxy-2-(4-pyridyl)-1,3-thiazole-5-carboxylate 

Downstream Products

• 1612886-74-4 4-phenyl-2-(pyridin-4-yl)thiazole-5-carbohydrazide 
• 1148158-15-9 N-hydroxy-4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxamide 
• 1612886-79-9 2-(4-phenyl-2-(pyridin-4-yl)thiazol-5-yl)-1,3,4-oxadiazole 

Relevant articles and documents

Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors

The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in the identification of a potent, selective Cdc7 inhibitor that decreased phosphorylation of the direct substrate MCM2 in vitro and in vivo, and inhibited DNA synthesis and cell viability in vitro.