114818-97-2

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 2930-05-4 (S)-benzyl glycidyl ether 
• 17690-16-3 benzyl bromomethyl ether 
• 42890-76-6 (S)-1,2,4-butanetriol 
• 100-39-0 benzyl bromide 
• 131068-45-6 (S)-1,4-bis(benzyloxy)-2-(methoxymethoxy)butane 

Downstream Products

• 1338379-16-0 C₁₉H₂₄O₅S 
• 42890-76-6 (S)-1,2,4-butanetriol 
• 131068-46-7 (R)-4-chloro-6-<<1,4-bis(benzyloxy)but-2-oxy>amino>-2,5-diformamidopyrimidine 
• 131078-82-5 (R)-6-chloro-9-<1,4-bis(benzyloxy)but-2-oxy>-2-formamidopurine 
• 114778-27-7 (R)-1,4-bis(benzyloxy)but-2-oxyamine 
• 114778-26-6 (R)-N-<1,4-bis(benzyloxy)but-2-oxy>phthalimide 

Relevant academic research and scientific papers

Preparation method of (S)-1, 2, 4-butantriol[7]

The invention relates to a preparation method of (S)-1, 2, 4-butantriol, which comprises the following steps: reacting (S)-benzyloxymethyl ethylene oxide with a magnesium halide Grignard reagent of benzyl halomethyl ether to obtain (S)-1, 4-dibenzyloxy-2-butanol; and under the action of a palladium-carbon catalyst, hydrogenating to remove a benzyl protecting group to obtain a final product. The method is short in synthetic route, less in three wastes and suitable for industrial production.

Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands

We designed and synthesized nonsecosteroidal vitamin D receptor (VDR) ligands that formed H-bonds with six amino acid residues (Tyr143, Ser233, Arg270, Ser274, His301 and His393) of the VDR ligand-binding domain. The ligand YR335 exhibited potent transcriptional activity, which was comparable to those of 1α,25-dihydroxyvitamin D3 and YR301. The crystal structure of the complex formed between YR335 and the VDR ligand-binding domain was solved, which revealed that YR335 formed H-bonds with the six amino acid residues mentioned above.

The asymmetric dihydroxylation of some alkenyl 2-acetylamino-2-deoxy-β-d-glucopyranosides: The preparation of optically pure epoxides as putative inhibitors of chitinases

Various alkenyl 2-acetylamino-2-deoxy-β-D-glucopyranosides have been subjected to the Sharpless asymmetric dihydroxylation protocol to yield the corresponding diols, albeit with somewhat disappointing stereoselectivity. An alternative, more traditional ap

Synthesis and Antiviral Activity of 9-Alkoxypurines. 2. 9-(2,3-Dihydroxypropoxy)-, 9-(3,4-Dihydroxybutoxy)-, and 9-(1,4-Dihydroxybut-2-oxy)purines

Reaction of alkenoxyamines (3, 5) or (R,S)-, (R)-, and (S)-hydroxy-protected derivatives of hydroxyalkoxyamines (20a,b, 37a-c) with 4,6-dichloro-2,5-diformamidopyrimidine (4) and cyclization of the resultant 6-- and 6-(alkoxyamino)pyrimid