114826-16-3

Upstream product

• 75-65-0 tert-butyl alcohol 
• 79026-61-2 (R)-3-benzyloxy-2-methylpropanal 
• 114826-14-1 (3R,4R)-5-Benzyloxy-2,4-dimethyl-pent-1-en-3-ol 
• 21329-14-6 lithium bis(isopropenyl)cuprate 

Downstream Products

• 114826-13-0 (2S,3R)-2-[(4S,5R,6S)-2,2,5-Trimethyl-6-((S)-1-methyl-2-phenylsulfanyl-ethyl)-[1,3]dioxan-4-yl]-pentan-3-ol 
• 114826-22-1 Acetic acid (3S,4R,5S,6R)-3-((R)-1-benzyloxymethoxy-propyl)-6-((R)-2-benzyloxy-1-methyl-ethyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-methyl-tetrahydro-pyran-2-yl ester 
• 114826-21-0 (2R,3R,4R,5S,6R)-3-((R)-1-Benzyloxymethoxy-propyl)-6-((R)-2-benzyloxy-1-methyl-ethyl)-4-(tert-butyl-dimethyl-silanyloxy)-5-methyl-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 114826-18-5 [(E)-(1R,2R,5R)-5-Benzyloxymethoxy-1-((R)-2-benzyloxy-1-methyl-ethyl)-2-hydroxy-2-methyl-hept-3-enyloxy]-acetic acid tert-butyl ester 
• 114826-20-9 (2R,3R,6R)-3-((R)-1-Benzyloxymethoxy-propyl)-6-((R)-2-benzyloxy-1-methyl-ethyl)-5-methyl-3,6-dihydro-2H-pyran-2-carboxylic acid methyl ester 
• 114826-19-6 (5R,6R)-6-((E)-(R)-3-Benzyloxymethoxy-pent-1-enyl)-5-((R)-2-benzyloxy-1-methyl-ethyl)-6-methyl-[1,4]dioxan-2-one 
• 114826-23-2 (2R,3R,4S,5R,6R)-7-Benzyloxy-2-((R)-1-benzyloxymethoxy-propyl)-4,6-dimethyl-heptane-1,3,5-triol 
• 114826-24-3 (4S,5S,6R)-4-((1S,2R)-2-Benzyloxymethoxy-1-methyl-butyl)-6-((R)-2-benzyloxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxane 

Relevant academic research and scientific papers

AN ALTERNATE ROUTE TO THE C(7)-C(13) SUBUNIT OF ERYTHRONOLIDE B VIA A HYDROPYRAN TEMPLATE

Conversion of (R)-3-benzyloxy-2-methylpropionaldehyde (4) to the erythronolide B C(7)-C(13) subunit 13 in the 15percent overall yield is described.Chelation-controlled carbonyl additions and a dioxanone-to-dihydropyran Claisen rearrangement are key steps.