114870-02-9

Basic information

• Product Name: Fondaparinux sodiuM interMediate A
• Synonyms: FSA
• CAS NO: 114870-02-9
• Molecular Formula: C31H53N3O40S5.7Na
• Molecular Weight: 1428.9863
• Mol File: 114870-02-9.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Fondaparinux sodiuM interMediate A(CAS DataBase Reference)
• NIST Chemistry Reference: Fondaparinux sodiuM interMediate A(114870-02-9)
• EPA Substance Registry System: Fondaparinux sodiuM interMediate A(114870-02-9)

Safety Data

• Hazardous Substances Data: 114870-02-9(Hazardous Substances Data)

Usage

General Description

Fondaparinux sodium Intermediate A is a chemical compound that is used in the synthesis of the anticoagulant drug fondaparinux sodium. It serves as an important intermediate in the production process, facilitating the conversion of precursor compounds into the final active pharmaceutical ingredient. Fondaparinux sodium is widely used for the prevention and treatment of deep vein thrombosis and pulmonary embolism, and this intermediate plays a crucial role in its manufacturing process. It is a key component in the pharmaceutical industry, contributing to the production of an important medication that helps to reduce the risk of blood clotting and associated complications.

Downstream Products

• 816468-88-9 fondaparinux 

Relevant articles and documents

Programmable One-Pot Synthesis of Heparin Pentasaccharide Fondaparinux

The clinically approved Fondaparinux (Arixtra) has been used for the treatment of deep vein thrombosis and acute pulmonary embolism since 2002 and is considered to be better than the low-molecular weight heparin in terms of anticoagulation response, duration of action, and biosafety. However, the synthetic methods previously developed for its manufacture are relatively complicated, thus restricting its extensive use. We report here a potentially scalable and programmable one-pot synthesis of Fondaparinux using the [1,2,2] strategy and designed thioglycosides with well-defined reactivity as building blocks.

PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM

The present invention refers to a fly step compounds of formula ABC5 novel sodium [...] provides manufacturing method: In some embodiments, step for the synthesis intermediates are sodium [...] fly is provided in addition. (by machine translation)

PROCESS FOR THE PRODUCTION OF FONDAPARINUX SODIUM

The present invention provides improved processes of preparing Fondaparinux sodium comprising converting a compound of formula ABCDE4 to Fondaparinux sodium at a reaction pH of no more than about 9.0. In some embodiments, the intermediates for the synthes