114872-19-4

Upstream product

• 114856-92-7 6-[4-(2-benzyloxycarbonylamino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone 
• 120757-13-3 4-(4-aminophenyl)-3-methyl-4-oxobutanoic acid hydrochloride 
• 122-85-0 para-acetamidobenzaldehyde 
• 42075-21-8 3-(4-acetamidobenzoyl)butyronitrile 
• 71818-74-1 (4-acetylamino-phenyl)-morpholin-4-yl-acetonitrile 
• 114856-93-8 2-{1,1-Dimethyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-isoindole-1,3-dione 
• 114856-90-5 {1,1-Dimethyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethyl}-carbamic acid tert-butyl ester 
• 114856-95-0 6-[4-(2-methyl-2-nitropropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone 
• 184766-13-0 3-[4-(2-methyl-2-nitropropylamino)benzoyl]butyric acid 

Relevant academic research and scientific papers

Studies on agents with vasodilator and β-blocking activities. IV

A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and β- blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Among them, the 5-chloro-2-cyanophenoxy derivative (29) showed the promising dual activities and was selected for further studies.

Antihypertensive pyridazinone aminoisopropanol derivatives

A pyridazinone derivative represented by the following general formula STR1 wherein R1 represents a hydrogen atom or a methyl group, either one of R2, R3 and R4 represents a hydrogen atom and the remaining two of them represent a lower alkyl group, a trifluoromethyl group, a halogen atom, a cyano group or a nitro group, and a salt thereof. The compounds are useful as antihypertensive agents.