120757-13-3

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-aminophenyl)-3-methyl-4-oxobutanoic acid hydrochloride is used as a key intermediate in the synthesis of analgesics, anti-inflammatory drugs, and other therapeutic agents. Its versatile chemical structure allows for the development of new and effective medications to treat various health conditions.
Used in Organic Synthesis and Drug Discovery Research:
As a reagent, 4-(4-aminophenyl)-3-methyl-4-oxobutanoic acid hydrochloride is utilized in organic synthesis and drug discovery research. Its unique properties make it a valuable tool for the development of new chemical compounds and the exploration of novel therapeutic approaches.
Used in Biochemical and Pharmacological Research:
4-(4-aminophenyl)-3-methyl-4-oxobutanoic acid hydrochloride is a potent inhibitor of serine proteases, which are enzymes involved in various biological processes. Its ability to inhibit these enzymes makes it a valuable tool in biochemical and pharmacological research, aiding in the understanding of enzyme function and the development of targeted therapies.

Upstream product

• 81937-39-5 2-ethoxycarbonyl-3-(4-acetamidobenzoyl)butyric acid ethyl ester 
• 42075-21-8 3-(4-acetamidobenzoyl)butyronitrile 
• 103-84-4 Acetanilid 
• 81112-08-5 N-[4-(2-chloro-1-oxopropyl)phenyl]acetamide 
• 184766-02-7 N-[4-(1,3-Dicyano-2-methyl-1-morpholin-4-yl-propyl)-phenyl]-acetamide 
• 122-85-0 para-acetamidobenzaldehyde 
• 71818-74-1 (4-acetylamino-phenyl)-morpholin-4-yl-acetonitrile 

Downstream Products

• 36725-28-7 6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone 
• 184766-13-0 3-[4-(2-methyl-2-nitropropylamino)benzoyl]butyric acid 
• 114872-19-4 6-[4-(2-amino-2-methylpropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone 
• 114856-95-0 6-[4-(2-methyl-2-nitropropylamino)phenyl]-5-methyl-4,5-dihydro-3(2H)-pyridazinone 
• 184766-81-2 4-Chloro-2-(3-{1,1-dimethyl-2-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenylamino]-ethylamino}-2-hydroxy-propoxy)-5-(tetrahydro-pyran-2-yloxy)-benzonitrile 

Relevant academic research and scientific papers

DIHYDROPYRIDAZINONES SUBSTITUTED WITH PHENYLUREAS

Compounds of formula (I) which are nicotinamide phosphoribosyltransferase (NAMPT) inhibitors and their use for the treatment of hyperproloferative diseases and/or disorders responsive to induction of cell death.

Synthesis and bioactivity of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives

A series of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives was prepared and examined for cardiotonic activity. The structures of these new pyridazinone derivatives were confirmed by IR, 1H-NMR and mass spectrum. The cardiotonic activities of these compounds were studied on isolated perfused toad heart and compared with the activity of levosimendan (CAS 141505-33-1). Compound 5a emerged as the most interesting compound in this series with potential cardiotonic activity. ECV Editio Cantor Verlag.

Studies on agents with vasodilator and β-blocking activities. IV

A series of novel pyridazinone derivatives (II) having a phenoxypropanolamine moiety was synthesized. Their hypotensive and β- blocking activities were evaluated after intravenous administration of the compounds to anesthetized rats. Among them, the 5-chloro-2-cyanophenoxy derivative (29) showed the promising dual activities and was selected for further studies.

6-(substituted phenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-ones of medicinal interest. The synthesis of SK&F 94836 and SK&F 95654

Two synthetic routes to the dihydropyridazinone-cyanoguanidine 4 (SK&F 94836) are described, both proceeding via the anilino compound 6. An efficient synthesis of the dihydropyridazinone-pyridone 5 (SK&F 95654) is reported. This synthesis proceeds via the fluoro-keto-acid 24, with subsequent displacement of the fluoro substituent by 4-pyridone. The surprising effectiveness of water as a solvent in this reaction has been highlighted.