114896-75-2

Upstream product

• 123-75-1 pyrrolidine 
• 70769-72-1 1-phenyl-3-ethylsulfenyl-2-buten-1-one 
• 63525-16-6 1-phenyl-3-chloro-2-buten-1-one 
• 83996-14-9 1-phenyl-3-(1-imidazolyl)-2-buten-1-one 
• 85143-88-0 1-(3-phenyl-3-oxo-1-buten-1-yl)-3-methylimidazolium iodide 
• 91859-93-7 3-(1-benzimidazolyl)-1-phenyl-2-buten-1-one 
• 91859-96-0 3-(3,5-dimethyl-1-pyrazolyl)-1-phenyl-2-buten-1-one 
• 91859-95-9 3-(3-methyl-1-pyrazolyl)-1-phenyl-2-buten-1-one 
• 91859-92-6 3-(2-methyl-1-imidazolyl)-1-phenyl-2-buten-1-one 
• 91859-94-8 3-(1-pyrazolyl)-1-phenyl-2-buten-1-one 
• 74896-63-2 1-phenyl-3-ethylsulfinyl-2-buten-1-one 
• 91859-97-1 (2-Brom-propenyl>-phenylketon 
• 42392-88-1 1-phenyl-3-methoxybut-2-en-1-one 

Relevant academic research and scientific papers

Reactivities of 3-(1-Azolyl)-2-alken-1-ones and the Related Compounds With Pyrrolidine

From the rate constants of the reaction with pyrrolidine, the reactivities of 3-(1-azolyl)-2-alken-1-ones with nucleophiles were evaluated to be rather high.Especially the reactivities of the quarternary salts of 3-(1-imidazolyl)-2-alken-1-ones were nearly equal to those of 3-chloro-2-alken-1-ones.In conclusion, 3-(1-imidazolyl)-2-alken-1-ones satisfied the practical requirements for the starting materials of the synthesis of 3-hetero-substituted 2-alken-1-ones.

The Reaction of 3-(1-Imidazolyl)-2-alken-1-ones with Nucleophiles

Generally 3-hetero-substituted 2-alken-1-ones were prepared from 1,3-alkanediones, 3-chloro-2-alken-1-ones, or conjugated ynones.The preparation of 3-hetero-substituted 2-alken-1-ones was subjected to some limitations by these methods.By the reaction of 3-(1-imidazolyl)-2-alken-1-ones (I) and 3-(3-oxo-1-alkenyl)-1-methylimidazolium iodides (II) with nucleophiles, 3-hetero-substituted 2-alken-1-ones could be obtained regioselectively in good yield under mild conditions.These results suggested that compounds I and II were concluded to be useful intermediates for the organic synthesis.