114967-63-4Relevant academic research and scientific papers
Tricyclic heteroaromatic systems: Synthesis, [3H]flunitrazepam brain membrane binding inhibition, and structure-activity relationships of 2,3-dihydro-2-aryl-4-R-[1]benzopyrano[4,3-c]pyrazole-3-ones
Colotta,Cecchi,Melani,Palazzino,Filacchioni,Martini,Giannaccini,Lucacchini
, p. 239 - 242 (2007/10/02)
We report the synthesis and binding activity to the central benzodiazepine receptors of some 2,3-dihydro-2-ary-4-R-[1]benzopyrano[4,3-c]pyrazole-3-ones, which are isosteres of the CGS series. Although the compounds of the CGS series are potent ligands of
THE CORRECT SYNTHESIS OF 2,3-DIHYDRO-2-ARYL-4-R-BENZOPYRANOPYRAZOLE-3-ONES.
Colotta, Vittoria,Cecchi, Lucia,Melani, Fabrizio,Palazzino, Giovanna,Filacchioni, Guido
, p. 5165 - 5168 (2007/10/02)
The correct synthesis of the title compounds 1a-b and 2a-b is described.The claimed synthesis of 2a from 2-methyl-3-chromonecarbonitrile is shown not to lead to 2a, as previously reported but to 1,4-dihydro-1-phenyl-3-methylbenzopyranopyrazole-4
