114967-89-4

Basic information

• Product Name: methyl {[(8xi,9xi,11beta,14xi)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl]sulfanyl}acetate
• CAS NO: 114967-89-4
• Molecular Formula: C₂₄H₃₄O₆S
• Molecular Weight: 450.5882
• Mol File: 114967-89-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 610.3°C at 760 mmHg
• Flash Point: 322.9°C
• Density: 1.29g/cm³
• Vapor Pressure: 1.92E-17mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: methyl {[(8xi,9xi,11beta,14xi)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl]sulfanyl}acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl {[(8xi,9xi,11beta,14xi)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl]sulfanyl}acetate(114967-89-4)
• EPA Substance Registry System: methyl {[(8xi,9xi,11beta,14xi)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl]sulfanyl}acetate(114967-89-4)

Safety Data

• Hazardous Substances Data: 114967-89-4(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 125118-27-6 N-hydroxysuccinimide (11β,17α-dihydroxy-4-pregnene-3,20-dion-21-ylthio)acetate 
• 33767-06-5 11β,17α-dihydroxy-21-iodopregn-4-ene-3,20-dione 
• 2365-48-2 Methyl thioglycolate 
• 63644-48-4 Cortisol 21-tosylate 
• 103782-07-6 (8S,9S,10R,11S,13S,14S,17R)-17-(2-Bromo-acetyl)-11,17-dihydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 98791-34-5 (11β,17α-Dihydroxy-4-pregnene-3,20-dion-21-yl-21-thio)acetic acid 
• 42271-17-0 sodium (2-methoxy-2-oxoethyl)sulfanide 

Downstream Products

• 114967-90-7 (11β,17α-Dihydroxy-4-pregnene-3,20-dion-21-yl-21-sulfenyl)acetic acid methyl ester 

Relevant articles and documents

SYNTHESIS OF N-HYDROXYSUCCINIMIDE ESTERS AND AMIDES OF THE 21-THIOALKANOIC ACIDS OF CORTICOSTEROIDS

The N-hydroxysuccinimide esters of the 21-thioalkanoic acids of corticosteroids were synthesized by the reaction of the 21-thioalkanoic acids of corticosteroids with N-hydroxysuccinimide in the presence of N,N-dicyclohexylcarbodiimide. Their reaction with ammonia and primary and secondary amines gave the amides of the acids, while their reaction with alcohols gave the esters.The amides were also obtained by the reaction of the 21-thioalkanoic acids of the corticosteroids with ammonia and amines in the presence of carbodiimides.The esters of the 21-thioalkanoic acids of the corticosteroids only form the amides in reaction with ammonia.The amides of the 21-thioalkanoic acids of corticosteroids can also be obtained from the 21-sulfonates and 21-halogen derivatives of the corticosteroids and mercaptoacetamides in the presence of bases or by heating in aprotic dipolar solvents.

SYNTHESIS AND ANTI-INFLAMMATORY ACTIVITY OF 21-THIO DERIVATIVES OF CORTICOSTEROIDS

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