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114976-76-0

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114976-76-0 Usage

Chemical Properties

White Needles

Uses

Different sources of media describe the Uses of 114976-76-0 differently. You can refer to the following data:
1. A competitive glycosidase inhibitor. It is also a glycoprotein mannosidase inhibitor - inhibiting jack bean, and to a lesser extent lysosomal alpha-mannosidase. It is an azofuranose analog of mannose, and is structurally related to swainsonine.
2. A competitive glycosidase inhibitor. It is also a glycoprotein mannosidase inhibitor - inhibiting jack bean, and to a lesser extent lysosomal alpha-mannosidase. It is an azofuranose analog of mannose, and is structurally related to swainsonine

Check Digit Verification of cas no

The CAS Registry Mumber 114976-76-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,9,7 and 6 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 114976-76:
(8*1)+(7*1)+(6*4)+(5*9)+(4*7)+(3*6)+(2*7)+(1*6)=150
150 % 10 = 0
So 114976-76-0 is a valid CAS Registry Number.

114976-76-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,4-Dideoxy-1,4-imino-D-mannitol, Hydrochloride

1.2 Other means of identification

Product number -
Other names 1,4-DIDEOXY-1,4-IMINO-D-MANNITOL HYDROCHLORIDE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114976-76-0 SDS

114976-76-0Downstream Products

114976-76-0Relevant articles and documents

Synthesis and glycosidase inhibition of: N-substituted derivatives of 1,4-dideoxy-1,4-imino-d-mannitol (DIM)

Yang, Lin-Feng,Shimadate, Yuna,Kato, Atsushi,Li, Yi-Xian,Jia, Yue-Mei,Fleet, George W. J.,Yu, Chu-Yi

, p. 999 - 1011 (2020/02/15)

N-Substituted derivatives of 1,4-dideoxy-1,4-imino-d-mannitol (DIM), the pyrrolidine core of swainsonine, have been synthesized efficiently and stereoselectively from d-mannose with 2,3:5,6-di-O-isopropylidene DIM (10) as a key intermediate. These N-substituted derivatives include N-alkylated, N-alkenylated, N-hydroxyalkylated and N-aralkylated DIMs with the carbon number of the alkyl chain ranging from one to nine. The obtained 33 N-substituted DIM derivatives were assayed against various glycosidases, which allowed a systematic evaluation of their glycosidase inhibition profiles. Though N-substitution of DIM decreased their α-mannosidase inhibitory activities, some of the derivatives showed significant inhibition of other glycosidases.

Efficient stereodivergent synthesis of 1,4-dideoxy-1,4-iminohexitols from an (S)-glyceraldimine

Badorrey, Ramón,Cativiela, Carlos,Díaz-De-Villegas, María D.,Díez, Roberto,Gálvez, José A.

, p. 719 - 722 (2007/10/03)

A stereodivergent synthesis of 1,4-dideoxy-1,4-imino-D-mannitol I and D-allitol III from an (S)-glyceraldimine, which is easily prepared from D-mannitol, has been achieved with overall yields of 62% and 49%, respectively. The synthesis is based on the add

Enantiospecific and stereoselective synthesis of polyhydroxylated pyrrolidines and indolizidines from trans-4-hydroxy-L-proline

Blanco, Maria-Jesus,Sardina, F. Javier

, p. 4748 - 4755 (2007/10/03)

We have developed a short, efficient, and stereoselective synthesis of polyhydroxylated pyrrolidine and indolizidine glycosidase inhibitors starting from 4-hydroxy-L-proline. The regio- and stereoselective hydroxylation of an N-Pf-4-oxoproline enolate and the stereoselective reduction of the resulting keto alcohol allowed us to introduce the cis diol present in the target compounds. The different side chains needed to complete the syntheses of the target compounds were introduced by reduction of the ester group of a substituted proline or by reaction of organolithium or organomagnesium reagents with the same group followed by stereoselective reduction of the resulting ketones. Hydrogenolysis of the alcohols thus obtained gave the hydrochlorides of the desired pyrrolidine glycosidase inhibitors, which were obtained in nine steps in overall yields greater than 50%. The indolizidine glycosidase inhibitor 8-epi-swainsonine was also prepared using this approach.

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