114989-67-2Relevant academic research and scientific papers
Studies on antiplatelet agents. I. Synthesis and platelet inhibitory activity of 5-alkyl-2-aryl-4-pyridylimidazoles
Tanaka,Ito,Nishino,Motoyama,Takasugi
, p. 3206 - 3213 (2007/10/02)
5-Alkyl-2-aryl-4-pyridylimidazoles were synthesized and tested in rat ex vivo platelet aggregation studies. Among these compounds, 2-(2-fluorophenyl)-5-methyl-4-(3-pyridyl)imidazole (25) was most potent, and showed 98% inhibition at a dose of 10 mg/kg (p.o.). 25 had inhibitory activity on cyclooxygenase, thromboxane A2 (TXA2) synthetase, and phosphodiesterase, and also showed inhibited KCl-induced contraction of rat aorta. All compounds have little acute toxicity and appear to be free of adverse effects on the stomach.
Pyridyl-imidazole compounds which have useful pharmaceutical activity
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, (2008/06/13)
A compound of the formula: STR1 wherein R1 is pyridyl, R2 is hydrogen, lower alkyl or hydroxy (lower) alkyl, R3 is hydrogen, hydroxy or lower alkyl, and R4 is aryl optionally substituted with substituent(s) sele
