115010-10-1

Basic information

• Product Name: BENZO[1,3]DIOXOLE-5-SULFONYL CHLORIDE
• Synonyms: OTAVA-BB BB7020430867;BENZO[1,3]DIOXOLE-5-SULFONYL CHLORIDE;1,3-BENZODIOXOLE-5-SULFONYL CHLORIDE;1,3-BENZODIOXOLE-5-SULPHONYL CHLORIDE;1,3-Benzodioxole-5-sulphonyl chloride 97%;benzo[d][1,3]dioxole-5-sulfonyl chloride;(2-phenyl-2H-1,3-dioxol-4-yl)(sulfonyl)chloranuide;1,3-Benzodioxole-5-sulphonyl chloride 95+%
• CAS NO: 115010-10-1
• Molecular Formula: C₇H₅ClO₄S
• Molecular Weight: 220.63
• Mol File: 115010-10-1.mol
• Article Data: 30

Chemical Properties

• Melting Point: 46-49
• Boiling Point: 326.5 °C at 760 mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.607 g/cm³
• Vapor Pressure: 0.000409mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: BENZO[1,3]DIOXOLE-5-SULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZO[1,3]DIOXOLE-5-SULFONYL CHLORIDE(115010-10-1)
• EPA Substance Registry System: BENZO[1,3]DIOXOLE-5-SULFONYL CHLORIDE(115010-10-1)

Safety Data

• Hazard Codes: C,Xi
• Statements: 14-34-36
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3261 8 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 115010-10-1(Hazardous Substances Data)

Usage

Uses

1,3-Benzodioxole-5-sulfonyl chloride is used as an organic chemical synthesis intermediate.

InChI:InChI=1/C7H5ClO4S/c8-13(9,10)5-1-2-6-7(3-5)12-4-11-6/h1-3H,4H2

Upstream product

• 271-97-6 benzodioxole 
• 79-37-8 oxalyl dichloride 
• 75-34-3 1,1-dichloroethane 
• 94839-07-3 3,4-(methylenedioxy)-benzeneboronic acid 
• 274-09-9 Methylenedioxybenzene 
• 107-06-2 1,2-dichloro-ethane 
• 143018-62-6 Potassium; benzo[1,3]dioxole-5-sulfonate 
• 69849-38-3 trimethyl(3,4-methylenedioxyphenyl)stannane 

Downstream Products

• 313681-94-6 tert-butyl N-((1S,2R)-1-[(4-benzyloxy)benzyl]-3-(5-tert-butyldimethylsilyloxy-2,2-dimethylpentyl)[(3,4-methylenedioxyphenyl)sulfonyl]amino-2-hydroxypropyl)carbamate 
• 288291-36-1 {(1S,2R)-3-[(Benzo[1,3]dioxole-5-sulfonyl)-(4-cyano-2,2-dimethyl-butyl)-amino]-1-benzyl-2-hydroxy-propyl}-carbamic acid tert-butyl ester 
• 180031-05-4 methyl 3-(benzo[1,3]dioxol-5-sulphonylamino)-4-(2-methoxy-phenoxy)-5-[2-(tetrahydro-pyran-2-yloxy)-ethoxy]-benzoate 
• 174303-68-5 1-[N-[(1,3-benzodioxol-5-yl) sulfonyl]-N-(2-methylpropyl)amino]-3(S)-[N,N-bis(phenylmethyl)amino]-4-phenyl-2(R)-butanol 
• 1447963-69-0 N-[2-(3,4-dimethoxyphenyl)ethyl]-1,3-benzodioxole-5-sulfonamide 

Relevant articles and documents

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME

ABSTRACT The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.

CHEMICAL COMPOUNDS

The present invention relates generally to novel therapeutic compounds and AXOR 109 agonists, and processes for the manufacture and use of the same.