115022-34-9Relevant academic research and scientific papers
Asymmetric tandem Claisen-ene strategy for convergent synthesis of (+)-9(11)-dehydroestrone methyl ether: Stereochemical studies on the ene cyclization and cyclic enol ether Claisen rearrangement for steroid total synthesis
Mikami, Koichi,Takahashi, Kazuhiko,Nakai, Takeshi,Uchimaru, Tadafumi
, p. 10948 - 10954 (2007/10/02)
An asymmetric synthesis of (+)-9(11)-dehydroestrone methyl ether (1), a key intermediate for estrogen analogs, is described using a new strategy of consecutive carbocyclizations for the D and C rings of the steroid skeleton based on an asymmetric tandem C
Stereochemical Control in Intramolecular Ene Reactions of Crotyl Propargyl Ether Systems
Mikami, Koichi,Takahashi, Kazuhiko,Nakai, Takeshi
, p. 2347 - 2350 (2007/10/02)
Stereochemical features are described of the title reactions leading to the γ-alkylidene-β-vinyloxolanes.Of particular interest is the high 1,2-trans diastereoselectivity observed for the (α-alkyl)crotyl and (α,β-dialkyl)crotyl ether systems with methoxyc
