148317-74-2Relevant academic research and scientific papers
Asymmetric tandem Claisen-ene strategy for convergent synthesis of (+)-9(11)-dehydroestrone methyl ether: Stereochemical studies on the ene cyclization and cyclic enol ether Claisen rearrangement for steroid total synthesis
Mikami, Koichi,Takahashi, Kazuhiko,Nakai, Takeshi,Uchimaru, Tadafumi
, p. 10948 - 10954 (2007/10/02)
An asymmetric synthesis of (+)-9(11)-dehydroestrone methyl ether (1), a key intermediate for estrogen analogs, is described using a new strategy of consecutive carbocyclizations for the D and C rings of the steroid skeleton based on an asymmetric tandem C
