1150271-14-9

Basic information

• Product Name: 6-Fluoro-8-methylquinoline
• Synonyms: 6-Fluoro-8-methylquinoline
• CAS NO: 1150271-14-9
• Molecular Formula: C₁₀H₈FN
• Molecular Weight: 161.1756232
• Mol File: 1150271-14-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-Fluoro-8-methylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-8-methylquinoline(1150271-14-9)
• EPA Substance Registry System: 6-Fluoro-8-methylquinoline(1150271-14-9)

Safety Data

• Hazardous Substances Data: 1150271-14-9(Hazardous Substances Data)

Usage

General Description

6-Fluoro-8-methylquinoline is a chemical compound with the molecular formula C10H8FN. It is a derivative of quinoline, with a fluorine atom at the 6th position and a methyl group at the 8th position on the quinoline ring. 6-Fluoro-8-methylquinoline is used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and biologically active molecules. It has also shown potential as a fluorescent probe for detecting biological molecules and as a building block for designing new materials with specific properties. 6-Fluoro-8-methylquinoline is a versatile chemical that has a wide range of applications in the fields of medicine, materials science, and chemical research.

Upstream product

• 452-71-1 4-fluor-2-methylaniline 
• 107-18-6 allyl alcohol 
• 56-81-5 glycerol 
• 14002-34-7 tripropanolamine 

Downstream Products

• 1609646-74-3 N-((6-fluoroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide 

Relevant articles and documents

Reduction of nitroarenes followed by propanol group transfer from tris(3-hydroxypropyl)- amine and cyclization leading to quinolines under heterogeneous Pd-C catalysis

Nitroarenes having electron-donating or -withdrawing substituents are reduced to anilines and cyclized with tris(3- hydroxypropyl)amine in the presence of a catalytic amount of Pd-C along with tin(II) chloride and isopropanol in dioxane-H2O medium to give the corresponding quinolines in good to excellent yields. Copyright

Cp?Rh(III)-Catalyzed Mild Addition of C(sp3)-H Bonds to α,β-Unsaturated Aldehydes and Ketones

A Rh(III)-catalyzed addition of benzylic C(sp3)-H bond to α,β-unsaturated ketones/aldehydes has been realized, leading to efficient synthesis of γ-aryl ketones/aldehydes. This atom-economic reaction proceeded under mild and redox-neutral conditions with a broad substrate scope. Besides benzylic C-H, allylic C-H bonds are also applicable when assisted by O-methyl ketoxime directing groups.

Rhodium(III)-Catalyzed Direct Coupling of Quinoline-8-Carbaldehydes with (Het)Arylboronic Acids for the Synthesis of 8-Aryloylquinolines

Herein, we describe a method for the synthesis of aryl-(het)aryl ketones by Rh(III)-catalyzed direct coupling between quinoline-8-carbaldehydes and (het)arylboronic acids. The method has a broad substrate scope, a high functional group tolerance, and uses

From Anilines to Quinolines: Iodide- and Silver-Mediated Aerobic Double C?H Oxidative Annulation–Aromatization

Quinoline synthesis from easily accessible raw materials such as anilines is a valuable and meaningful task. Herein, we communicate an iodide- and silver-mediated C?H/C?H oxidative annulation–aromatization between anilines and allyl alcohols. This protocol provides a direct route to the synthesis of quinoline derivatives from inexpensive commodities. Various kinds of anilines, even heterocyclic anilines, were shown to be workable substrates, generating the corresponding multi-substituted quinolines in good yields.