1150617-57-4

Basic information

• Product Name: 1-(bromomethyl)-4-cyclopropylbenzene
• Synonyms: 1-(bromomethyl)-4-cyclopropylbenzene
• CAS NO: 1150617-57-4
• Molecular Formula: C₁₀H₁₁Br
• Molecular Weight: 211
• Mol File: 1150617-57-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 272.079 °C at 760 mmHg
• Flash Point: 127.265 °C
• Appearance: /
• Density: 1.437 g/cm³
• CAS DataBase Reference: 1-(bromomethyl)-4-cyclopropylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(bromomethyl)-4-cyclopropylbenzene(1150617-57-4)
• EPA Substance Registry System: 1-(bromomethyl)-4-cyclopropylbenzene(1150617-57-4)

Safety Data

• Hazardous Substances Data: 1150617-57-4(Hazardous Substances Data)

Usage

Description

1-(Bromomethyl)-4-cyclopropylbenzene is an organic compound characterized by its bromine atom attached to a methyl group, which is in turn connected to a cyclopropylbenzene ring. This structure endows it with unique chemical properties and potential applications in various fields.

Uses

1. Used in Pharmaceutical Industry:
1-(Bromomethyl)-4-cyclopropylbenzene is used as a protein tyrosine phosphatase 1B (PTP1B) inhibitor for the treatment of type II diabetes. Its chemical structure allows it to interact with the PTP1B enzyme, thereby modulating its activity and potentially improving glucose metabolism and insulin sensitivity in patients with type II diabetes.
2. Used in Chemical Synthesis:
1-(Bromomethyl)-4-cyclopropylbenzene can also be utilized as a building block or intermediate in the synthesis of more complex organic compounds, particularly those with pharmaceutical or agrochemical applications. Its unique structure and reactivity make it a valuable component in the development of novel molecules with specific biological activities.
3. Used in Research and Development:
In academic and industrial research settings, 1-(Bromomethyl)-4-cyclopropylbenzene may be employed as a model compound to study various chemical reactions and mechanisms. Its distinct structural features can provide insights into the behavior of similar compounds and contribute to the advancement of synthetic chemistry and related fields.

Upstream product

• 454678-87-6 4-cyclopropyl-benzenemethanol 
• 20034-50-8 4-cyclopropylbenzaldehyde 

Downstream Products

• 1396260-29-9 1-(4-cyclopropylbenzyl)-7-methyl-3-(β-D-xylopyranosyl)-1H-indole 
• 1396260-31-3 1-(4-propylbenzyl)-3-(β-D-xylopyranosyl)-1H-indole 
• 1396260-26-6 1-(4-cyclopropylbenzyl)-7-fluoro-3-(β-D-xylopyranosyl)-1Hindole 
• 1396260-23-3 1-(4-cyclopropylbenzyl)-3-(β-D-xylopyranosyl)-1H-indole 

Relevant articles and documents

SUBSTITUTED XANTHINE DERIVATIVES

The present invention relates to compounds of formula (I) a process for their manufacture, pharmaceutical compositions containing them and their use in therapy, particularly in the treatment of conditions having an association with TRPC5 containing ion channels. R1, R2, R3, R4 and R5 have meanings given in the description.

Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors

Sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors are the current focus on the indication for the management of hyperglycemia in diabetes. Here, a novel series of C-linked indolylxyloside-based inhibitors of SGLT2 has been discovered. Structure-activity relationship studies revealed that substituents at the 7-position of the indole moiety and a p-cyclopropylphenyl group in the distal position were necessary for optimum inhibitory activity. The pharmacokinetic study demonstrates that the most potent compound 1i is metabolically stable with a low clearance in rats. In further efficacy study, 1i is found to significantly lower blood glucose levels of streptozotocin (STZ)-induced diabetic rats.