20034-50-8

Basic information

• Product Name: 4-CYCLOPROPYLBENZALDEHYDE
• Synonyms: 4-CYCLOPROPYLBENZALDEHYDE;AKOS BAR-1174;p-Cyclopropylbenzaldehyde
• CAS NO: 20034-50-8
• Molecular Formula: C₁₀H₁₀O
• Molecular Weight: 146.19
• Mol File: 20034-50-8.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-CYCLOPROPYLBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CYCLOPROPYLBENZALDEHYDE(20034-50-8)
• EPA Substance Registry System: 4-CYCLOPROPYLBENZALDEHYDE(20034-50-8)

Safety Data

• Hazardous Substances Data: 20034-50-8(Hazardous Substances Data)

Usage

General Description

4-Cyclopropylbenzaldehyde is a chemical compound with the molecular formula C10H10O and a molecular weight of 146.18 g/mol. It is a colorless liquid that is insoluble in water but soluble in organic solvents. 4-CYCLOPROPYLBENZALDEHYDE is commonly used as a building block in the synthesis of pharmaceuticals, fragrances, and other organic compounds. Its unique chemical structure, which includes a cyclopropyl ring attached to a benzene ring with an aldehyde group, gives it potential applications in the development of new drugs and materials. 4-Cyclopropylbenzaldehyde is known for its strong, aromatic odor and is typically handled and stored in a well-ventilated area due to its potentially hazardous nature.

Upstream product

• 4885-02-3 Dichloromethyl methyl ether 
• 873-49-4 cyclopropylbenzene 
• 1122-91-4 4-bromo-benzaldehyde 
• 411235-57-9 cyclopropylboronic acid 
• 26979-32-8 7-Cyclopropylcycloheptatrien 
• 3002-94-6 cyclopropyllithium 
• 192436-83-2 4-bromo-N-methoxy-N-methylbenzamide 
• 925430-09-7 tricyclopropylbismuthane 
• 201230-82-2 carbon monoxide 
• 15164-44-0 p-(iodophenyl)carboxaldehyde 
• 261635-93-2 2-methyl-6-(trifluoromethyl)pyridine-3-carboxylic acid 
• 68-12-2 N,N-dimethyl-formamide 
• 104-88-1 4-chlorobenzaldehyde 
• 1124-14-7 1-bromo-4-cyclopropylbenzene 

Downstream Products

• 875109-29-8 2-benzyloxyphenyl-(4-cyclopropylphenyl)methanol 
• 1396260-23-3 1-(4-cyclopropylbenzyl)-3-(β-D-xylopyranosyl)-1H-indole 
• 1396260-26-6 1-(4-cyclopropylbenzyl)-7-fluoro-3-(β-D-xylopyranosyl)-1Hindole 
• 1396260-29-9 1-(4-cyclopropylbenzyl)-7-methyl-3-(β-D-xylopyranosyl)-1H-indole 
• 1150617-57-4 p-cyclopropylbenzyl bromide 
• 1396260-31-3 1-(4-propylbenzyl)-3-(β-D-xylopyranosyl)-1H-indole 
• 1798-82-9 4-cyclopropylbenzoic acid 
• 1255305-40-8 tert-butyl 3-[4-(4-cyclopropylbenzyloxy)-3-methoxyphenyl]azetidine-1-carboxylate 
• 1255305-39-5 1-(4-cyclopropylbenzyloxy)-4-iodo-2-methoxybenzene 
• 454678-61-6 3-(β-D-glucopyranosyloxy)-5-methyl-4-[(4-cyclopropylphenyl)methyl]-1H-pyrazole 

Relevant articles and documents

Gold Catalysts Can Generate Nitrone Intermediates from a Nitrosoarene/Alkene Mixture, Enabling Two Distinct Catalytic Reactions: A Nitroso-Activated Cycloheptatriene/Benzylidene Rearrangement

Gold-catalyzed reactions of cycloheptatrienes with nitrosoarenes yield nitrone derivatives efficiently. This reaction sequence enables us to develop gold-catalyzed aerobic oxidations of cycloheptatrienes to afford benzaldehyde derivatives using CuCl and nitrosoarenes as co-catalysts (10-30 mol %). Our density functional theory calculations support a novel nitroso-activated rearrangement, tropylium → benzylidene. With the same nitrosoarenes, we developed their gold-catalyzed [2 + 2 + 1]-annulations between nitrosobenzene and two enol ethers to yield 5-alkoxyisoxazolidines using 1,4-cyclohexadienes as hydrogen donors.

Optimization of an azetidine series as inhibitors of colony stimulating factor-1 receptor (CSF-1R) Type II to lead to the clinical candidate JTE-952

Optimization of novel azetidine compounds, which we had found as colony stimulating factor-1 receptor (CSF-1R) Type II inhibitors, provided JTE-952 as a clinical candidate with high cellular activity (IC50 = 20 nM) and good pharmacokinetics pro

Palladium-Catalyzed Carbonylative Cross-Coupling Reaction between Aryl(Heteroaryl) Iodides and Tricyclopropylbismuth: Expedient Access to Aryl Cyclopropylketones

The carbonylative cross-coupling reaction between aryl and heteroaryl iodides and tricyclopropylbismuth is reported. The reaction is catalyzed by (SIPr)Pd(allyl)Cl, a NHC-palladium(II) catalyst, operates under 1 atm of carbon monoxide and tolerates a wide range of functional groups. The use of lithium chloride was found to provide higher yields of the desired aryl cyclopropylketones. The conditions were also applied to the carbonylative cross-coupling of an iodoalkene to afford the corresponding alkenyl cyclopropylketone.