115084-37-2

Usage

Indole ring structure

A core structure consisting of a 5-membered nitrogen-containing ring fused to a 6-membered aromatic ring.

Methoxy groups

Two methoxy (-OCH3) functional groups present, one located at the 5-position and another at the 4-position relative to the indole ring, which can influence the compound's reactivity and solubility.

Methyl group

A single methyl (-CH3) group attached at the 3-position of the indole ring, further modifying the compound's properties and reactivity.

Organic compound

The compound is a carbon-based molecule, which is typical for organic chemistry research and applications.

Potential pharmaceutical applications

Due to its complex structure and various functional groups, the compound may have potential uses in the pharmaceutical industry, such as drug development or targeted therapies.

Material science applications

The compound's unique structure and properties may make it suitable for use in materials science, such as in the development of new polymers or other advanced materials.

Dependence on arrangement and interactions

The specific properties and uses of the compound are influenced by the arrangement and interactions of its chemical constituents, requiring further research and analysis to fully understand its potential applications.

Upstream product

• 629-03-8 1 ,6-dibromohexane 
• 91444-18-7 5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole 
• 21086-33-9 2-bromo-1-(4-methoxyphenyl)-1-propanone 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 127451-82-5 5-Methoxy-2-(4-methoxy-phenyl)-3-methyl-1-(6-pyrrolidin-1-yl-hexyl)-1H-indole 
• 116041-09-9 5-methoxy-2-(4-methoxyphenyl)-3-methyl-1-(6-phthalimidohexyl)indole 
• 137591-93-6 2-Pyridyl--indolylketon 
• 127451-88-1 {6-[5-Methoxy-2-(4-methoxy-phenyl)-3-methyl-indol-1-yl]-hexyl}-dimethyl-amine 
• 127451-87-0 {6-[5-Methoxy-2-(4-methoxy-phenyl)-3-methyl-indol-1-yl]-hexyl}-methyl-amine 
• 115084-39-4 1-(2-amino-ethylamino)-6-[5-hydroxy-2-(4-hydroxyphenyl)-3-methyl-indole-1-yl]-hexane 
• 115084-42-9 1-(6-amino-hexyl)-5-methoxy-2-(4-methoxyphenyl)-3-methyl-indole 
• 116041-12-4 2-(4-Hydroxy-phenyl)-3-methyl-1-{6-[(pyridin-2-ylmethyl)-amino]-hexyl}-1H-indol-5-ol 
• 116041-11-3 {6-[5-Methoxy-2-(4-methoxy-phenyl)-3-methyl-indol-1-yl]-hexyl}-[1-pyridin-2-yl-meth-(E)-ylidene]-amine 
• 116041-10-2 {6-[5-Methoxy-2-(4-methoxy-phenyl)-3-methyl-indol-1-yl]-hexyl}-pyridin-2-ylmethyl-amine 
• 132751-96-3 2-(4-Hydroxy-phenyl)-3-methyl-1-[6-(1-pyridin-2-yl-ethylamino)-hexyl]-1H-indol-5-ol 
• 132751-91-8 {6-[5-Methoxy-2-(4-methoxy-phenyl)-3-methyl-indol-1-yl]-hexyl}-(1-pyridin-2-yl-ethyl)-amine 
• 132751-86-1 {6-[5-Methoxy-2-(4-methoxy-phenyl)-3-methyl-indol-1-yl]-hexyl}-[1-pyridin-2-yl-eth-(E)-ylidene]-amine 
• 132751-97-4 2-(4-Hydroxy-phenyl)-3-methyl-1-[6-(1-pyridin-2-yl-propylamino)-hexyl]-1H-indol-5-ol 

Relevant academic research and scientific papers

2-phenylindoles as antiestrogenic pharmaceutical agents

PCT No. PCT/EP95/03000 Sec. 371 Date May 14, 1997 Sec. 102(e) Date May 14, 1997 PCT Filed Jul. 27, 1995 PCT Pub. No. WO96/03375 PCT Pub. Date Feb. 8, 1996Novel 2-phenyl indoles are disclosed of general formula (I), wherein: R1 represents one of the rests -(CH2)n-S(O)m-R4, -(CH2)n-NR6-SO2-R4, (a), and n' being integers between 4 and 12 and m and m' are 0, 1 or 2; X represents a methylene group, an imino group =NR6, or an oxygen or sulphur atom; R2 and R3 independently of one another represent a hydrogen atom, a C1-C10 alkyl group, a benzyl, alkanoyl or alkanoyloxy, or carbarnoyl rest of formula -C(O)R5 or -C(O)NR6R7 or a tetrahydropyranyl group; R4 represents a hydrogen atom, a C1-C10 alkyl, a completely or partially fluorinated alkyl group -(CH2)o-(CF2)pCF3, o and p being independently of one another integers between 0 and 6, an (alkyl)amino or (alkyl)carbamoyl group of formula (CH2)q-Y-NR8R9, q being an integer between 0 and 6 and Y representing a direct bond, a methylene or carbamoyl group (a condition being that q cannot be 0 when Y is a carbonyl group and m is 2), an aryl, aralkyl or heteroaryl group; R5 represents a C1-C10 alkyl group or a C1-C10 alkoxy group, a phenyl or benzyl group; R6, R7, R8 and R9 independently of one another represent a hydrogen atom, a C1-C10 alkyl group, or a benzyl group; and R10 represents a methyl group and R11 represents a hydrogen atom, or R10 and R11 both represent a di-, tri- or tetramethylene bridge which can also have a C-C double bond at any location in the bridge. These novel compounds have strong and selective anti-oestrogen properties and are suitable for use in particular in the treatment of oestrogen-related diseases.

Platinum Complexes with Binding Affinity for the Estrogen Receptor

A number of (1,2-diaminoethane)dichloroplatinum(II) complexes, linked to dihydroxy-2-phenylindole by spacer groups of varying lengths, were synthesized and studied for their binding affinities for the calf uterine estrogen receptor.Best binding conditions