115091-77-5

Basic information

• Product Name: 2-amino-4-(4-methoxyphenyl)-4H,5H-thiochromeno[4,3-b]pyran-3-carbonitrile
• Synonyms: 4H,5H-[1]benzothiopyrano[4,3-b]pyran-3-carbonitrile, 2-amino-4-(4-methoxyphenyl)-
• CAS NO: 115091-77-5
• Molecular Formula: C₂₀H₁₆N₂O₂S
• Molecular Weight: 348.4182
• Mol File: 115091-77-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 645.4°C at 760 mmHg
• Flash Point: 344.1°C
• Density: 1.37g/cm³
• Vapor Pressure: 1.51E-16mmHg at 25°C
• Refractive Index: 1.706
• CAS DataBase Reference: 2-amino-4-(4-methoxyphenyl)-4H,5H-thiochromeno[4,3-b]pyran-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-4-(4-methoxyphenyl)-4H,5H-thiochromeno[4,3-b]pyran-3-carbonitrile(115091-77-5)
• EPA Substance Registry System: 2-amino-4-(4-methoxyphenyl)-4H,5H-thiochromeno[4,3-b]pyran-3-carbonitrile(115091-77-5)

Safety Data

• Hazardous Substances Data: 115091-77-5(Hazardous Substances Data)

Upstream product

• 74074-07-0 3-(4-methoxy-benzylidene)-thiochroman-4-one 
• 109-77-3 malononitrile 
• 3528-17-4 2,3-dihydro-4H-[1]benzothiopyran-4-one 
• 123-11-5 4-methoxy-benzaldehyde 
• 74074-07-0 (Z)-3-(4-methoxy-benzylidene)-thiochroman-4-one 

Downstream Products

• 135521-76-5 1-amino-4-(4-methoxyphenyl)-4H,5H-<1>benzothiopyrano<4,3-b>pyran-3-carbonitrile-6-sulfone 

Relevant articles and documents

Green chemistry preparation of thiochromeno[4,3-b]pyran and benzo[h]thiazolo[2,3-b]quinazoline derivatives using HSBM technique over ZnAl2o4 nano-powders

Aim and Objective: The aim of this paper is to introduce HSBM as a green and environmentally friendly technique for the synthesis of thiochromeno[4,3-b]pyran and benzo[h]thiazolo[2,3-b]quinazoline derivatives over ZnAl2O4 nanopowders

Synthesis of novel tricyclic heterocyclic compounds as potential anticancer agents using chromanone and thiochromanone as synthons

The arylmethylene of benzopyrane or benzothiopyrane 3,4 have been synthesized and condensed with hydrazine, guanidine and thiourea to yield pyrazole 5-8, aminopyrimidine 9,10 and thioxopyrimidine derivatives 11,12, respectively. Compounds 3 or 4 on treatment with malononitrile in the presence of ammonium acetate/acetic acid or in the presence of piperidine/ methanol to yield benzopyrano- and benzothiopyranopyridine 13,14 and benzopyrano- and benzothiopyrane 15,16, respectively. The oxirane of compound 3 is prepared and condensed with CS2 to yield the tricyclic system, thioxothienobenzopyrane 21. Ylidenemalononitrile for the ketone 1 and 2 are synthesized and condensed with aromatic aldehyde in presence of ammonium acetate/acetic acid to yield benzopyranopyridine and benzothiopyranopyridine derivatives 24,25, respectively, which are the isomer of compounds 13,14. Ylidenemalononitrile on condensation with phenylisothiocyanate yields benzo-pyrano- and benzothiopyranothioxopyridine 28,29, respectively.

A New Synthesis of Benzothiopyrano-pyridines and -pyrans.

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