115114-22-2Relevant academic research and scientific papers
Enantioselectivity of muscarinic antagonists. Isomeric 2-cyclohexyl-2-phenyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodides
Romanelli,Gualtieri,Valle,Brasili,Angeli
, p. 1703 - 1708 (2007/10/02)
The four isomers of 2-cyclohexyl-2-phenyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodide were prepared. Their absolute configuration was attributed by means of X-ray crystallography and circular dichroism. The compounds were tested on rat bladder an
Cholinergic antagonists carrying a 1,3-oxathiolane nucleus
Angeli,Giannella,Pigini,et al.
, p. 517 - 523 (2007/10/02)
The synthesis and cholinergic activity of a series of 2-substituted-5-dimethylaminomethyl-1,3-oxathiolane methiodide is reported. The compounds are competitive muscarinic antagonists and show a pattern of potencies which is fairly close to that of the corresponding 1,3-dioxolane compounds. Structure-activity relationship studies showed that antagonists of both series interact with the same receptor site, but at the same time failed to prove whether the site, at least partly, coincides with that recognized by the agonists. In any case it appears fairly probable that the agonists of the 1,3-oxathiolane and 1,3-dioxolane series share the same binding site.
