115131-08-3Relevant academic research and scientific papers
ON-DEMAND PHOSPHORAMIDITE SYNTHESIS
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Page/Page column 36-38, (2022/01/24)
The invention relates to a method of synthesis of phosphoramidites by immobilization of a phosphitylation agent on a resin activated to create a charged resin, then putting in contact with the charged resin with a suitable substrate. Phosphoramidites are synthesized in a few minutes from the application of the starting materials. Thus, the process makes it possible to create specific phosphoramidites on demand when they are needed in other applications. The substrates to be applied are mainly nucleosides, thus making it possible to create nucleoside phosphoramidites for the subsequent synthesis of oligonucleotides.
OLIGODEOXYNUCLEOSIDE METHYLPHOSPHONATES: SYNTHESIS AND ENZYMIC DEGRADATION
Agrawal, Sudhir,Goodchild, John
, p. 3539 - 3542 (2007/10/02)
The automated synthesis of oligodeoxynucleosides containing methylphosphonate linkages has been improved by using nucleoside methylphosphonamidites as starting materials.It was found that two adjacent methylphosphonate linkages protect an oligomer from degradation by snake venom phosphodiesterase or spleen phosphodiesterase.
