1151561-00-0Relevant academic research and scientific papers
NEW SMAC MIMETIC COMPOUNDS AS APOPTOSIS INDUCERS
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Page/Page column 109, (2009/06/27)
The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of a
Rational design, synthesis and characterization of potent, non-peptidic Smac mimics/XIAP inhibitors as proapoptotic agents for cancer therapy
Seneci, Pierfausto,Bianchi, Aldo,Battaglia, Cristina,Belvisi, Laura,Bolognesi, Martino,Caprini, Andrea,Cossu, Federica,Franco, Elena de,Matteo, Marilenia de,Delia, Domenico,Drago, Carmelo,Khaled, Amira,Lecis, Daniele,Manzoni, Leonardo,Marizzoni, Moira,Mastrangelo, Eloise,Milani, Mario,Motto, Ilaria,Moroni, Elisabetta,Potenza, Donatella,Rizzo, Vincenzo,Servida, Federica,Turlizzi, Elisa,Varrone, Maurizio,Vasile, Francesca,Scolastico, Carlo
experimental part, p. 5834 - 5856 (2009/12/06)
Novel proapoptotic Smac mimics/IAPs inhibitors have been designed, synthesized and characterized. Computational models and structural studies (crystallography, NMR) have elucidated the SAR of this class of inhibitors, and have permitted further optimizati
