1151643-06-9Relevant academic research and scientific papers
A new synthesis of 1,4-dihydropyridine derevatives from formyl furochromone
Fawzy
experimental part, p. 169 - 182 (2009/04/06)
Condensation of equimolar β-enaminoester (2a-d), β-ketoester (3a-c) with formyl furochromone (1) yielded 1,4-dihydropyridine derivatives (4a-1). Oxidation of 1,4-dihydropyridine derivatives (4a-c) afforded the corresponding pyridine derivatives (5a-c). Reaction of compound (1) with β-enaminoester (2a-d) in the molar ratio (1:2) gave 1,4-dihydropyridine derivatives (6a-d). Treatnent of formyl furochromone (1) with 3-aminocrotononitrile (7) in the molar ratio (1: 2) in an acid medium yielded 1,4-dihydropyridine derivatives (11). It has been found that compound (1) react with nitroketenaminals (12a-d) to give 1,4-dihydropyridine (13a-d). Reduction of nitro-group on 1,4-dihydropyridine (13a) gave compound (14a).
