115175-17-2

Basic information

• Product Name: 3-AMINO-N-(4-CHLOROPHENYL)BENZAMIDE
• Synonyms: 3-AMINO-N-(4-CHLOROPHENYL)BENZAMIDE;OTAVA-BB 1056964;UKRORGSYN-BB BBV-019249;3-amino-N-(4-chlorophenyl)benzamide(SALTDATA: FREE);Benzamide, 3-amino-N-(4-chlorophenyl)-
• CAS NO: 115175-17-2
• Molecular Formula: C₁₃H₁₁ClN₂O
• Molecular Weight: 246.7
• Mol File: 115175-17-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 351.271°C at 760 mmHg
• Flash Point: 166.243°C
• Appearance: /
• Density: 1.351g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.692
• CAS DataBase Reference: 3-AMINO-N-(4-CHLOROPHENYL)BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-N-(4-CHLOROPHENYL)BENZAMIDE(115175-17-2)
• EPA Substance Registry System: 3-AMINO-N-(4-CHLOROPHENYL)BENZAMIDE(115175-17-2)

Safety Data

• Hazardous Substances Data: 115175-17-2(Hazardous Substances Data)

Usage

General Description

3-AMINO-N-(4-CHLOROPHENYL)BENZAMIDE is a chemical compound with the molecular formula C13H11N2OCl. It consists of a benzene ring with an amino group and a chlorophenyl group attached to it. 3-AMINO-N-(4-CHLOROPHENYL)BENZAMIDE is commonly used in pharmaceutical research and development as a potential drug candidate. It has been studied for its potential biological activities, including its anticancer and anti-inflammatory properties. Additionally, it has been identified as a potential target for drug design due to its ability to interact with specific biological receptors.

InChI:InChI=1/C13H11ClN2O/c14-10-4-6-12(7-5-10)16-13(17)9-2-1-3-11(15)8-9/h1-8H,15H2,(H,16,17)

Upstream product

• 99514-24-6 N-(4-chloro-phenyl)-3-nitro-benzamide 
• 121-92-6 3-nitrobenzoic acid 
• 121-90-4 m-nitrobenzoic acid chloride 

Downstream Products

• 1233188-81-2 3-(2-chloro-acetylamino)-N-(4-chloro-phenyl)-benzamide 
• 1414781-47-7 C₁₄H₁₁ClN₂OS₂*C₆H₁₂N₂ 
• 251446-22-7 5-Acetyl-1-ethyl-2-oxo-2,3-dihydro-1H-indole-3-carboxylic acid [3-(4-chloro-phenylcarbamoyl)-phenyl]-amide 

Relevant articles and documents

Synthesis and in Vitro and in Vivo anticoagulant and antiplatelet activities of amidino- and non-amidinobenzamides

Three amidino- and ten non-amidinobenzamides were synthesized as 3-aminobenzoic acid scaffold-based anticoagulant and antiplatelet compounds. The anticoagulant activities of thirteen synthesized compounds 1-13, and 2b and 3b as prodrugs were preliminary evaluated by screening the prolongation of activated partial thromboplastin time (aPTT) and prothrombin time (PT) in vitro. From the aPTT results obtained, two amidinobenzamides, N-(3′-amidinophenyl)-3-(thiophen-2″-ylcarbonylamino) benzamide (1, 33.2 ± 0.7 s) and N-(4′-amidinophenyl)-3-(thiophen-2″-ylcarbonylamino) benzamide (2, 43.5 ± 0.6 s) were selected to investigate the further anticoagulant and antiplatelet activities. The aPTT results of 1 (33.2± 0.7 s) and 2 (43.5 ± 0.6 s) were compared with heparin (62.5 ± 0.8 s) in vitro at 30 μM. We investigated the effect of 1 and 2 on blood anticoagulant activity (ex vivo) and on tail bleeding time (in vivo) on mice. A tail cutting/bleeding time assay revealed that both 1 and 2 prolonged bleeding time in mice at a dose of 24.1 g/mouse and above. Compounds 1 and 2 dose-dependently inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation. In addition, 1 and 2 were evaluated on the inhibitory activities of thrombin and FXa as well as the generation of thrombin and FXa in human umbilical vein endothelial cells (HUVECs). Collectively, 1 and 2 possess some antiplatelet and anticoagulant activities and offer a basis for development of a novel antithrombotic product.