99514-24-6

Basic information

• Product Name: N-(4-chloro-phenyl)-3-nitro-benzamide
• Synonyms: N-(4-chloro-phenyl)-3-nitro-benzamide
• CAS NO: 99514-24-6
• Molecular Weight: 276.679
• Mol File: 99514-24-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(4-chloro-phenyl)-3-nitro-benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chloro-phenyl)-3-nitro-benzamide(99514-24-6)
• EPA Substance Registry System: N-(4-chloro-phenyl)-3-nitro-benzamide(99514-24-6)

Safety Data

• Hazardous Substances Data: 99514-24-6(Hazardous Substances Data)

Upstream product

• 121-92-6 3-nitrobenzoic acid 
• 99-61-6 3-nitro-benzaldehyde 
• 106-47-8 4-chloro-aniline 
• 121-90-4 m-nitrobenzoic acid chloride 
• 2243-73-4 5-nitrobenzanilide 

Downstream Products

• 115175-17-2 3-amino-N-(4-chloro-phenyl)-benzamide 
• 861081-29-0 3-nitro-benzoic acid-(4-chloro-2,6-dinitro-anilide) 
• 5388-62-5 4-chloro-2,6-dinitroaniline 

Relevant articles and documents

Direct oxidative amidation of aldehydes with anilines under mechanical milling conditions

(Chemical Equation Presented) Oxone is found to be an effective oxidant for the oxidative amidation of aldehydes with anilines to furnish amides in a one-pot process under mechanical milling conditions.

Synthesis and in Vitro and in Vivo anticoagulant and antiplatelet activities of amidino- and non-amidinobenzamides

Three amidino- and ten non-amidinobenzamides were synthesized as 3-aminobenzoic acid scaffold-based anticoagulant and antiplatelet compounds. The anticoagulant activities of thirteen synthesized compounds 1-13, and 2b and 3b as prodrugs were preliminary evaluated by screening the prolongation of activated partial thromboplastin time (aPTT) and prothrombin time (PT) in vitro. From the aPTT results obtained, two amidinobenzamides, N-(3′-amidinophenyl)-3-(thiophen-2″-ylcarbonylamino) benzamide (1, 33.2 ± 0.7 s) and N-(4′-amidinophenyl)-3-(thiophen-2″-ylcarbonylamino) benzamide (2, 43.5 ± 0.6 s) were selected to investigate the further anticoagulant and antiplatelet activities. The aPTT results of 1 (33.2± 0.7 s) and 2 (43.5 ± 0.6 s) were compared with heparin (62.5 ± 0.8 s) in vitro at 30 μM. We investigated the effect of 1 and 2 on blood anticoagulant activity (ex vivo) and on tail bleeding time (in vivo) on mice. A tail cutting/bleeding time assay revealed that both 1 and 2 prolonged bleeding time in mice at a dose of 24.1 g/mouse and above. Compounds 1 and 2 dose-dependently inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation. In addition, 1 and 2 were evaluated on the inhibitory activities of thrombin and FXa as well as the generation of thrombin and FXa in human umbilical vein endothelial cells (HUVECs). Collectively, 1 and 2 possess some antiplatelet and anticoagulant activities and offer a basis for development of a novel antithrombotic product.