115178-80-8

Usage

Uses

Used in Pharmaceutical Industry:
2-(benzoyloxy)-(N-methyl-N-acetyl)acetamide is utilized as a precursor in the development of new medications, leveraging its amide-based structure for potential therapeutic benefits.
Used in Anti-inflammatory Applications:
In the medical field, 2-(benzoyloxy)-(N-methyl-N-acetyl)acetamide is used as an anti-inflammatory agent, potentially helping to reduce inflammation and associated discomfort.
Used in Analgesic Applications:
2-(benzoyloxy)-(N-methyl-N-acetyl)acetamide also serves as an analgesic, indicating its use in alleviating pain, which can be beneficial in various clinical settings.
Safety Considerations:
It is crucial to handle 2-(benzoyloxy)-(N-methyl-N-acetyl)acetamide with care, adhering to established safety guidelines to mitigate any potential hazards associated with its use.

Upstream product

• 108-24-7 acetic anhydride 
• 106231-50-9 2-(benzoyloxy)-N-methylacetamide 
• 532-32-1 sodium benzoate 
• 64649-43-0 (aminocarbonyl)methyl benzoate 
• 54150-57-1 2-benzoyloxyacetyl chloride 
• 614-44-8 benzoyloxyacetic acid 

Relevant academic research and scientific papers

Glycolamide esters as biolabile prodrugs of carboxylic acid agents: synthesis, stability, bioconversion, and physicochemical properties.

Benzoic acid esters of various substituted 2-hydroxyacetamides (glycolamides) were found to be hydrolyzed extremely rapidly in human plasma solutions, the half-lives of hydrolysis being less than 5 s in 50% plasma solutions for some N,N-disubstituted glycolamide esters. The rapid rate of hydrolysis could be largely attributed to cholinesterase (also called pseudocholinesterase) present in plasma. From a study of a variety of substituted glycolamide esters and structurally related esters, the most prominent structural requirement needed for a rapid rate of hydrolysis was found to be the glycolamide ester structure combined with the presence of two substituents on the amide nitrogen atom. A structural similarity of such esters with benzoylcholine, a good substrate for cholinesterase, was put forward. Esters of N,N-disubstituted glycolamides are suggested to be a useful biolabile prodrug type for several carboxylic acid agents. The esters combine a high susceptibility to undergo enzymatic hydrolysis in plasma with a high stability in aqueous solution. Furthermore, as demonstrated with the benzoic acid model esters, it is feasible to obtain ester derivatives with almost any desired water solubility or lipophilicity with retainment of marked lability to enzymatic hydrolysis.