1151944-61-4Relevant academic research and scientific papers
Synthesis and biological evaluation of 5-benzylidenerhodanine-3-acetic acid derivatives as AChE and 15-LOX inhibitors
Shafii, Negah,Khoobi, Mehdi,Amini, Mohsen,Sakhteman, Amirhossein,Nadri, Hamid,Moradi, Alireza,Emami, Saeed,Saeedian Moghadam, Ebrahim,Foroumadi, Alireza,Shafiee, Abbas
, p. 389 - 395 (2015)
A series of 5-benzylidenerhodanine-3-acetamides bearing morpholino-, 4-arylpiperazinyl-, or 4-benzylpiperidinyl- moieties were synthesized and their inhibitory activities against acetylcholinesterase (AChE) were evaluated. Alteration of amide part and substitution on the benzylidene moiety resulted in change of anti-AChE activity. The most active compound was the 1-benzylpiperidinyl derivative containing 4-(dimethylamino)benzylidene scaffold. Notably, the intermediate compounds, namely 5-arylidene-rhodanine-3-acetic acids (3), showed mild inhibitory activity against 15-lipoxygenase (15-LOX), while the final compound 4 showed no activity against 15-LOX.
Antimicrobial activity of rhodanine-3-acetic acid derivatives
Krátky, Martin,Vin?ová, Jarmila,Stola?íková, Ji?ina
, p. 1839 - 1845 (2017/03/08)
Twenty-four 2-(4-oxo-2-thioxothiazolidin-3-yl)acetic acid (rhodanine-3-acetic acid)-based amides, esters and 5-arylalkylidene derivatives were synthesized, characterized and evaluated as potential antimicrobial agents against a panel of bacteria, mycobact
