1152-51-8Relevant academic research and scientific papers
One-pot synthesis of salicylanilides by direct amide bond formation from salicyclic acid under microwave irradiation
Lu, Cheng-Rong,Zhao, Bei,Jiang, Ying-Peng,Ding, Hao,Yang, Sheng
, p. 1257 - 1266 (2011)
A highly efficient protocol for the preparation of aromatic amides is described by the direct reactions between salicyclic acid and aromatic amines in the presence of phosphorous trichloride under microwave irradiation. The method has several advantages over the conventional methods, including operational simplicity, good yield, and reduced reaction time.
Intra- versus intermolecular hydrogen bonds in salicylamide derivatives
Etter, Margaret C.,Urbanczyk-Lipkowska, Zofia,Ameli, Touradj M.,Panunto, Thomas W.
, p. 491 - 507 (1988)
The crystal structures, solid-state infrared patterns, and thermal properties of two polymorphs of 4′-nitrosalicylanilide are presented. In both polymorphs, intramolecular hydrogen bonds are found between the phenol oxygen and the amide proton, and interm
Synthesis and biological evaluation of JL-A7 derivatives as potent ABCB1 inhibitors
Pan, Miaobo,Cui, Jian,Jiao, Lei,Ghaleb, Hesham,Liao, Chen,Zhou, Jiaqi,Kairuki, Mutta,Lin, Haiyan,Huang, Wenlong,Qian, Hai
, p. 4194 - 4202 (2017/07/05)
Cancer chemotherapy failure is often due to the overexpression of ATP-binding cassette (ABC) transporters (particularly ABCB1), resulting in a variety of structurally and pharmacologically unrelated drugs efflux. The multidrug resistance (MDR) phenomenon could be reversed by ABCB1 inhibitors. Now, JL-A7 as the lead compound based on a triazol-N-ethyl-tetrahydroisoquinoline scaffold, 18 compounds were designed and synthesized. Substitution in para positions yielded high activities toward ABCB1. Moreover, compound 5 could effectively block the drug efflux function of ABCB1 and increase the accumulation of anti-cancer drugs to achieve effective treatment concentration in MDR cells.
PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES
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, (2012/05/07)
A new class of salicylanilides is described. These compounds show strong activity against hepatitis viruses.
Synthesis of Substituted Salicylanilides under Microwave Irradiation
Veverkova, Eva,Meciarova, Maria,Toma, Stefan,Balko, Jozef
, p. 1215 - 1219 (2007/10/03)
Salicylanilides were prepared in 70-95% yields in 4-8 min from phenyl salicylate or phenyl 4-methoxysalicylate and substituted anilines under microwave irradiation under solvent free conditions.
