6082-87-7

Basic information

• Product Name: 2-(4-NITROPHENOXY)BENZENECARBOXYLIC ACID
• Synonyms: 2-(4-NITROPHENOXY)BENZENECARBOXYLIC ACID;AKOS BC-0775
• CAS NO: 6082-87-7
• Molecular Formula: C₁₃H₉NO₅
• Molecular Weight: 259.21
• Mol File: 6082-87-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 154-157°C
• Appearance: /
• CAS DataBase Reference: 2-(4-NITROPHENOXY)BENZENECARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-NITROPHENOXY)BENZENECARBOXYLIC ACID(6082-87-7)
• EPA Substance Registry System: 2-(4-NITROPHENOXY)BENZENECARBOXYLIC ACID(6082-87-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6082-87-7(Hazardous Substances Data)

Usage

General Description

2-(4-Nitrophenoxy)benzenecarboxylic acid is a chemical compound with the molecular formula C13H9NO6. It is a crystalline solid with a pale yellow color and is commonly used in the synthesis of pharmaceuticals and organic compounds. 2-(4-NITROPHENOXY)BENZENECARBOXYLIC ACID is a derivative of benzoic acid and contains a 4-nitrophenoxy group. It is often utilized in the production of dyes, pigments, and other organic materials due to its ability to form stable chemical bonds. Additionally, this compound exhibits potential anti-inflammatory and analgesic properties, making it a valuable building block in the pharmaceutical industry.

Upstream product

• 62256-41-1 2-(4-nitrophenoxy)benzaldehyde 
• 2243-42-7 2-phenoxybenzoic acid 
• 100-00-5 4-chlorobenzonitrile 
• 212189-50-9 methyl2-(4-nitrophenoxy)benzoate 
• 350-46-9 4-Fluoronitrobenzene 
• 119-36-8 methyl salicylate 
• 108-95-2 phenol 
• 118-91-2 ortho-chlorobenzoic acid 
• 17374-48-0 Salicylsaeure-4-nitrophenylester 
• 100-02-7 4-nitro-phenol 
• 2444-29-3 1-methyl-2-(4-nitrophenoxy)benzene 

Downstream Products

• 91692-78-3 2-(4-nitro-phenoxy)-benzoyl chloride 
• 934668-64-1 2-(4-aminophenoxy)-N-(2-methoxyphenyl)benzamide 
• 440111-88-6 morpholino(2-(4-nitrophenoxy)phenyl)methanone 
• 1391741-40-4 N-(2-(hydroxymethyl)phenyl)-2-(4-nitrophenoxy)benzamide 
• 934668-63-0 N-(2-methoxyphenyl)-2-(4-nitrophenoxy)benzamide 
• 873986-45-9 2-(4-iodo-phenoxy)-benzoic acid 
• 212189-58-7 methyl2-(4-aminophenoxy)benzoate 
• 1152-51-8 4'-nitrosalicylanilide 
• 384861-84-1 5-nitro-2-(4-nitro-phenoxy)-benzoic acid 
• 106163-95-5 2-(4-nitro-phenoxy)-benzoic acid amide 
• 67724-03-2 2-(4-amino-phenoxy)-benzoic acid 
• 212189-50-9 methyl2-(4-nitrophenoxy)benzoate 

Relevant articles and documents

2-(4-Nitrophenoxy)benzoic acid: A three-dimensional hydrogen-bonded framework in a triclinic structure having Z′ = 3

The title compound, C13H9NO5, crystallizes in space group P1..., with Z′ = 3. The molecules are linked by O-H...O hydrogen bonds [H...O = 1.79-1.81 A, O...O = 2.625 (3)-2.648 (3) A and O-H...O = 172-176°] into two types of R22(8) dimer, only one of which is centrosymmetric. An extensive series of soft hydrogen bonds, of C-H...O and C-H...π(arene) types, links the dimers into a three-dimensional framework.

Derivatives of quinoline as inhibitors for MEK

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof. wherein: n is 0-1; X and Y are independently selected from -NH-, -O-, -S-, or -NR8- where R8 is alkyl of 1-6 carbon atoms and X may additionally comprise a CH2 group; R7 is a group (CH2)mR9 where m is 0,or an integer of from 1-3 and R9 is a substituted aryl group, an optionally substituted cycloalkyl ring of up to 10 carbon atoms, or an optionally substituted heterocyclic ring or an N-oxide of any nitrogen containing ring; R6 is a divalent cycloalkyl of 3 to 7 carbon atoms, which may be optionally further substituted with one or more alkyl of 1 to 6 carbon atom groups; or is a divalent pyridinyl, pyimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally further substituted with one or more specified groups; R1, R2, R3 and R4 are each independently selected from hydrogen or various specified organic groups. Compounds are useful as pharmaceuticals for the inhibition of MEK activity.