115210-51-0Relevant articles and documents
Discovery of 1-(4-phenoxypiperidin-1-yl)-2-arylaminoethanone stearoyl-CoA desaturase 1 inhibitors
Zhao, Hongyu,Serby, Michael D.,Smith, Harriet T.,Cao, Ning,Suhar, Tom S.,Surowy, Teresa K.,Camp, Heidi S.,Collins, Christine A.,Sham, Hing L.,Liu, Gang
, p. 3388 - 3391 (2007)
A series of novel stearoyl-CoA desaturase 1 (SCD1) inhibitors were identified by scaffold design based on known SCD1 inhibitors. Large structural changes were made leading to multiple analogs with comparable or improved potency. This approach is valuable
