1152308-70-7Relevant academic research and scientific papers
Highly suppressing wild-type HIV-1 and Y181C mutant HIV-1 strains by 10-chloromethyl-11-demethyl-12-oxo-calanolide A with druggable profile
Xue, Hai,Lu, Xiaofan,Zheng, Purong,Liu, Li,Han, Chunyan,Hu, Jinping,Liu, Zijie,Ma, Tao,Li, Yan,Wang, Lin,Chen, Zhiwei,Liu, Gang
, p. 1397 - 1401 (2010)
We herein report a new compound: 10-chloromethyl-11-demethyl-12-oxo- calanolide A (20, EC50 = 7.4 nM, SI = 1417), which demonstrates a druggable profile with 32.7% oral bioavailability in rat, tolerated oral single dose toxicity in mice, and especially the feature of highly efficient suppression of the wild-type HIV-1 and Y181C mutant HIV-1 at an EC50 = 7.4 nM and EC50 = 0.46 nM, respectively.
TETRIACYCLODIPYRANYL COUMARINS AND THE ANTI-HIV AND ANTI-TUBERCULOSIS USES THEREOF
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Page/Page column 73, (2010/08/18)
The present invention relates to tctracyclodipyrano-coumarin compounds of general formula (I), wherein the substituents are defined herein. These compounds exihibit dual biological activities of anti human immunodeficiency virus type 1 (HIV-1) infection a
