115231-49-7

Upstream product

• 827-41-8 3-phenylpyrazol-5-amine 
• 545-06-2 trichloroacetonitrile 
• 1572-10-7 3⁽⁵⁾-phenylpyrazol-5⁽³⁾-amine 
• 127099-85-8 N-Cyanoguanidine 

Relevant academic research and scientific papers

Synthesis and antileukemic activity of new fluorinated 5-aza-9-deazapurines1

Novel fluorinated 4-benzylamino-7-phenylpyrazolo[1,5-a]-[1,3,5]triazin-2-amines were prepared using an efficient and practical approach. The chemoselectivity of condensation of pyrazolylguanidine and trichloroacetonitrile was found to be solvent-dependent

4-Amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines: A new practical synthesis and biological activity

The trichloromethyl moiety was successfully employed as a leaving group in nucleophilic substitutions with various amines for the synthesis of 4-amino-substituted pyrazolo[1,5-a][1,3,5]triazin-2-amines. The key precursor for this reaction, 4-trichloromethylpyrazolo[1,5-a][1,3,5]triazin-2-amine, was prepared via the solvent-dependent condensation of 5-guanidino-3-phenylpyrazole with trichloroacetonitrile. In a broad biological activity screening, some of the prepared compounds were identified as CGRP receptor antagonists.