127099-85-8Relevant articles and documents
A New Method for Converting Thiourea and Monosubstituted Thioureas into Cyanamides: Desulphurisation by Superoxide Ion
Crank, George,Makin, Mahommad I. H.
, p. 53 - 54 (1984)
Superoxide ion, in aprotic media, converts thiourea and monosubstituted thioureas into cyanamides.
Kinetics of the reaction of β-methoxy-α-nitrostilbene with cyanamide in 50% DMSO-50% water. Failure to detect the S(N)V intermediate
Bernasconi, Claude F.,Leyes, Aquiles E.,Rappoport, Zvi
, p. 2897 - 2902 (1999)
A kinetic study of the reaction of β-methoxy-α-nitrostilbene (1-OMe) with cyanamide (CNA) over a pH range from 8.5 to 12.4 shows that it is the anion (CNA-, pK(a) = 11.38) rather than the neutral amine that is the reactive species. Attempts at monitoring the reaction with the neutral CNA at low pH were unsuccessful because of competing hydrolysis. It is shown that the nucleophilic reactivity of CNA is abnormally low, probably because of a resonance effect, and that the reactivity of CNA- is high, higher than that of strongly basic oxyanion because of relatively weak solvation. The high reactivity of both 1-OMe and CNA- appeared to constitute favorable conditions conducive to the detection of the S(N)V intermediate, as has been the case in the reactions of 1-OMe with thiolate ions, alkoxide ions, and some amines. However, no intermediate was observed. Reasons for this failure are discussed.
Nitrosation of Cyanamide: Preparation and Properties of the Elusive E- and Z-N'-Cyanodiazohydroxides
Guethner, Thomas,Huber, Evi,Sans, Juergen,Thalhammer, Franz
supporting information, (2020/04/29)
Nitrosation of cyanamide leads to unstable E/Z-cyanodiazohydroxides that easily deprotonate to E/Z-cyanodiazotates. Pursuing observations of E. Drechsel 145 years ago, the structure and reactivity of those products was determined, mainly in aqueous solution. Depending on the pH, three different thermal decomposition pathways give either N2O + HCN or N2 + HNCO. They were evaluated experimentally and by quantum mechanical calculations.
Novel method for synthesis of sulphaguanidine
Singh, Vikram,Kaushik
experimental part, p. 645 - 648 (2012/05/04)
The microwave-enhanced synthesis of sulphaguanidine is achieved rapidly and in good yield via the step-wise reaction of cyanamide with sulphonamide in the presence of acidic alumina or montmorillonite clays (KSF and K10).
Formation of pyrimidin-2-ylcyanamide and 2-aminopyrimidine in the reaction of aniline derivatives with cyanamide and dimethylamino-1-pyridyl-2-propenone
Koroleva,Ignatovich, Zh.V.,Ignatovich,Gusak
scheme or table, p. 1222 - 1226 (2011/12/01)
Substituted o- and p-nitroanilines and m-benzylaminoanilines in the reaction with cyanamide failed to yield the corresponding arylguanidines, and in the presence of 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one formed 4-pyridyl-substituted pyrimidin-2-ylcyanamides and 2-amino-pyrimidines.
Reaction of N-(carbamimidoyl)thiourea with 1-benzoyl-2-phenylacetylene
Glotova,Dvorko,Albanov,Protsuk
, p. 121 - 125 (2007/10/03)
1-Benzoyl-2-phenylacetylene reacted with N-(carbamimidoyl)thiourea in glacial acetic acid saturated with 20% HBr to give (4,6-diphenyl-2H-1,3-thazin- 2-ylidene)guanidine hydrobromide. The reaction of the same compounds in anhydrous ethanol in the presence
Cationic phenyl and chloro-platinum(II) complexes with cyanamides and cyanoguanidine. X-ray structure of trans-[Pt(Ph)(NCNMe2)(PPh 3)2][BPh4]
Ferreira, Cristina M.P.,Guedes Da Silva, M. Fátima C.,Duarte, Teresa,Fraústo Da Silva, Jo?o J.R.,Pombeiro, Armando J.L.,Michelin, Rino A.,Kukushkin, Vadim Yu.
, p. 395 - 402 (2008/10/08)
The phenyl-platinum(II) organocyanamide trans-[Pt(Ph)(NCNR 2)(PPh3)2][BPh4] (R=Me 1a, Et 1b) or cyanoguanidine cis-[Pt(Ph){NCNC(NH2)2}(PPh 3)2][BPh4] (2) complexes have been prepared by treatment of cis-[PtCl2(PPh3)2] in THF with NCNR2 or NCNC(NH2)2, respectively, in the presence of Na[BPh4], whereas the cyanoguanidine chloro-complex cis-[PtCl{NCNC(NH2)2}(PPh3)2] [BF4] (3) has been obtained by using Tl[BF4] instead of Na[BPh4]. Complex 3 reacts further with cyanoguanidine, in the presence of Na[BPh4], to produce the di(cyanoguanidine) cis-[Pt{NCNC(NH2)2nf>)2][BPh 4]2 complex 5, whereas the amine complex cis-[PtCl(NH 2R′)(PPh3)2][BF4] (R′=CH2C6H4Me-4, 4) is formed on reaction of the former with NH2R′ in CH2Cl 2. The X-ray structure of 1a is also reported.
2-substituted-4-nitrogen heterocycles as modulators of chemokine receptor activity
-
, (2008/06/13)
The present application describes modulators of CCR3 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
CRF receptor antagonists and methods relating thereto
-
, (2008/06/13)
CRF receptor antagonists are disclosed which have utility in the treatment of a variety of disorders, including the treatment of disorders manifesting hypersecretion of CRF in a warm-blooded animals, such as stroke. The CRF receptor antagonists of this invention have the following structure: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein m, R, R1, R2, A, X, Y and Z are as defined herein. Compositions containing a CRF receptor antagonist in combination with a pharmaceutically acceptable carrier are also disclosed, as well as methods for use of the same.
Bis(trimesitylgermylcarbodiimido)germylene, trimesitylgermylcyanamide and trimesitylgermylcarbodiimide
Rivière-Baudet, Monique,Dahrouch, Mohamed,Gornitzka, Heinz
, p. 153 - 157 (2007/10/03)
Bis(trimesitylgermylcarbodiimido)germylene (1), isolated as a white precipitate from the reaction of lithium trimesitylgermylcyanamide with dichlorogermylene, is stable at room temperature in the absence of water and oxygen. The germylene structure is pre
