115256-13-8Relevant articles and documents
A preparing method of a dofetilide intermediate
-
Paragraph 0045; 0073-0074, (2018/07/06)
A preparing method of a dofetilide intermediate and analogues thereof is disclosed. The method includes steps of dissolving a compound of the formula (I) into a reaction solvent, converting -NO2 of the compound of the formula (I) into -NH2 through hydroge
Selective class III antiarrhythmic agents. 1. Bis(arylalkyl)amines
Cross,Arrowsmith,Thomas,Gwilt,Burges,Higgins
, p. 1151 - 1155 (2007/10/02)
A series of bis(arylalkyl)amines is described and their effects on prolonging effective refractory period in isolated cardiac tissue listed. Most compounds prolonged the cardiac action potential without significantly altering the maximum rate of depolarization and may be defined as selective class III antiarrhythmic agents. It was found that a particularly advantageous structural feature was to have a methanesulfonamido moiety on both of the aryl rings. Thus, compound 16 [1-(4-methanesulfonamidophenoxy)-2-[N-(4-methanesulfonamidophenethyl)- N-methylamine]ethane] was selected for further investigations. The compound is highly potent and selective class III agent which acts by blockade of cardiac potassium channels.