1152617-24-7

Basic information

• Product Name: (3-Chloro-4-iodopyridin-2-yl)amine
• Synonyms: (3-Chloro-4-iodopyridin-2-yl)amine;3-Chloro-4-iodo-2-pyridinamine;3-Chloro-4-Iodopyridin-2-Amine
• CAS NO: 1152617-24-7
• Molecular Formula: C₅H₄ClIN₂
• Molecular Weight: 254.45613
• Mol File: 1152617-24-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 308.9±42.0 °C(Predicted)
• Appearance: /
• Density: 2.139±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 3.25±0.47(Predicted)
• CAS DataBase Reference: (3-Chloro-4-iodopyridin-2-yl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: (3-Chloro-4-iodopyridin-2-yl)amine(1152617-24-7)
• EPA Substance Registry System: (3-Chloro-4-iodopyridin-2-yl)amine(1152617-24-7)

Safety Data

• Hazardous Substances Data: 1152617-24-7(Hazardous Substances Data)

Usage

General Description

(3-Chloro-4-iodopyridin-2-yl)amine is a chemical compound with the molecular formula C5H3ClIN2. It is a heterocyclic building block used in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. (3-Chloro-4-iodopyridin-2-yl)amine is characterized by the presence of a pyridine ring with a chlorine atom at the 3-position and an iodine atom at the 4-position, as well as an amine group attached to the 2-position. Its unique structure and functional groups make it a versatile intermediate for various synthetic applications, and it is also used in the development of new materials and chemical products. Additionally, it can also be used as a reagent in organic synthesis to introduce the pyridine ring and amine group into target molecules.

Upstream product

• 1480-64-4 3-chloro-2-fluoropyridine 
• 796851-05-3 3-chloro-2-fluoro-4-iodopyridine 
• 889865-45-6 2,3-dichloro-4-iodopyridine 
• 2402-77-9 2,3-dichloro-pyridine 

Downstream Products

• 1414370-75-4 8-chloro-7-(4-fluorophenyl)-2-phenylimidazo[1,2-a]pyridine 
• 1414370-76-5 ethyl 8-chloro-7-(4-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate 
• 1414370-78-7 8-chloro-7-(p-tolylethynyl)-2-phenylimidazo[1,2-a]pyridine 
• 1414370-79-8 ethyl 8-chloro-7-(p-tolylethynyl)imidazo[1,2-a]pyridine-2-carboxylate 
• 1414370-84-5 8-chloro-2-phenylimidazo[1,2-a]pyridine-7-carbonitrile 
• 1414370-90-3 N-(8-chloro-2-phenylimidazo[1,2-a]pyridin-7-yl)aniline 
• 1414370-91-4 ethyl 8-chloro-7-(cyclohexylamino)imidazo[1,2-a]pyridine-2-carboxylate 
• 1414371-05-3 7-(4-fluorophenyl)-2-methyl-8-(pyridin-4-yl)imidazo[1,2-a]pyridine 
• 1414371-06-4 8-(fur-2-yl)-7-(p-tolylethynyl)-2-phenylimidazo[1,2-a]pyridine 
• 1414371-07-5 2-phenyl-8-(thien-3-yl)imidazo[1,2-a]pyridine-7-carbonitrile 
• 1414371-08-6 2-phenyl-8-(pyridin-4-yl)imidazo[1,2-a]pyridine-7-carbonitrile 
• 1414371-13-3 ethyl 7-(cyclohexylamino)-8-(pyridin-4-yl)imidazo[1,2-a]pyridine-2-carboxylate 
• 1414371-25-7 8-chloro-7-iodo-2-phenylimidazo[1,2-a]pyridine 
• 1416551-60-4 8-chloro-7-iodo-2-methylimidazo[1,2-a]pyridine 

Relevant articles and documents

MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING ACTIVITY OF SHP2

Provided herein is a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme, wherein LG, A, n, m and p are as defined in the Summary of the Invention, said manufacture including the manufacture and use of a compound of the formula VI, wherein R1 is a secondary amino protecting group and R5 is unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted aryl.

MANUFACTURE OF COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2

The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention.

Pyrazinothiazole compound and application thereof, and pharmaceutical composition containing pyrazinothiazole compound

The invention discloses a pyrazinothiazole compound, an application of the pyrazinothiazole compound, and a pharmaceutical composition containing the pyrazinothiazole compound, and provides a pyrazinothiazole compound represented by a formula A or a pharmaceutically acceptable salt of the pyrazinothiazole compound. The pyrazinothiazole compound provided by the invention has relatively good SHP2 inhibitory activity.