1152633-07-2Relevant academic research and scientific papers
Oxidative aromatic C-N bond formation: Convenient synthesis of N-amino-3-nitrile-indoles via FeBr3-mediated intramolecular cyclization
Zheng, Zisheng,Tang, Lina,Fan, Yanfeng,Qi, Xiuxiang,Du, Yunfei,Zhang-Negrerie, Daisy
experimental part, p. 3714 - 3725 (2011/06/27)
A variety of functionalized N-amino-3-nitrile-indole derivatives are obtained via an intramolecular hetero-cyclization of 2-aryl-3-substituted hydrazono-alkylnitriles using FeBr3 as a single electron oxidant. This approach allows the N-moiety on the side-chain to be annulated to the benzene ring during the final synthetic step via direct oxidative aromatic C-N bond formation.
