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8-Bromo-2-chloro-7-fluoroquinoline, also known as 8-BCFQ, is a heterocyclic chemical compound characterized by a quinoline ring with bromine, chlorine, and fluorine substituents. It is utilized in the synthesis of pharmaceuticals and agrochemicals, and has been investigated for its potential anti-cancer and antiviral activities. Additionally, 8-BCFQ serves as a building block for the production of other functionalized quinoline derivatives and can be employed as a fluorescent probe in biological and biochemical assays due to its unique spectral properties. However, caution is advised in handling 8-BroMo-2-chloro-7-fluoroquinoline due to its potential hazardous properties.

1152781-66-2

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1152781-66-2 Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
8-BCFQ is used as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals, contributing to the development of new drugs and pesticides.
Used in Anticancer and Antiviral Research:
8-Bromo-2-chloro-7-fluoroquinoline is used as a potential therapeutic agent in the research and development of treatments for cancer and viral infections, due to its demonstrated biological activities.
Used in the Production of Functionalized Quinoline Derivatives:
As a building block, 8-BCFQ is utilized in the synthesis of other quinoline-based compounds, expanding the range of applications for quinoline chemistry.
Used as a Fluorescent Probe in Biological and Biochemical Assays:
8-Bromo-2-chloro-7-fluoroquinoline is employed as a fluorescent probe in various assays, taking advantage of its unique spectral properties to track and study biological processes and interactions.

Check Digit Verification of cas no

The CAS Registry Mumber 1152781-66-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,2,7,8 and 1 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1152781-66:
(9*1)+(8*1)+(7*5)+(6*2)+(5*7)+(4*8)+(3*1)+(2*6)+(1*6)=152
152 % 10 = 2
So 1152781-66-2 is a valid CAS Registry Number.

1152781-66-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 8-Bromo-2-chloro-7-fluoroquinoline

1.2 Other means of identification

Product number -
Other names 8-Bromo-2-chloro-7-fluoro-quinoline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1152781-66-2 SDS

1152781-66-2Relevant academic research and scientific papers

5-HETEROARYL-PYRIDIN-2-AMINE CONFOUNDS AS NEUROPEPTIDE FF RECEPTOR ANTAGONISTS

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, (2021/02/12)

The present invention relates to novel aminopyridine derivatives of the general formula (I) and pharmaceutical compositions comprising these compounds, as well as their therapeutic use, particularly as neuropeptide FF (NPFF) receptor antagonists, including, e.g., for the treatment or prevention of pain, opioid-induced hyperalgesia, or addiction.

Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with in Vivo Efficacy against MRSA

Chen, Anna,Cummings, Jason E.,Duncan, Leonard R.,English, Anthony,Koci, Bryan,Li, Linsen,Lindert, Steffen,Lu, Yanran,Mann, Chelsea A.,Mcelroy, Craig A.,Mitton-Fry, Mark J.,Nolan, Sheri,Okumu, Antony,Papa, Jonathan L.,Ratigan, Steven C.,Roth, Brieanna,Seffernick, Justin T.,Slayden, Richard A.,Vibhute, Sandip,Wozniak, Daniel J.,Yalowich, Jack

, p. 15214 - 15249 (2021/10/25)

Novel bacterial topoisomerase inhibitors (NBTIs) are among the most promising new antibiotics in preclinical/clinical development. We previously reported dioxane-linked NBTIs with potent antistaphylococcal activity and reduced hERG inhibition, a key safet

HETEROCYCLIC COMPOUNDS AND USES THEREOF

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, (2019/10/23)

In recognition of the unmet need to develop novel therapeutic agents, the present invention discloses a novel class of heterocycles as dual inhibitors of BRD4 and class I PI3Ks. The compounds claimed herein could be used alone or in combination therapies

5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents

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Page/Page column 12, (2010/02/17)

The present invention relates to compounds of formula I, processes and intermediates for their production and their use as anti-inflammatory agents.

5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino-1-arylquinolin-2-ones, a process for their production and their use as anti-inflammatory agents

-

Page/Page column 20, (2010/03/02)

The present invention relates to compounds of formula I, processes and intermediates for their production and their use as antiinflammatory agents.

5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, A Process for Their Production and Their Use as Anti-inflammatory Agents

-

Page/Page column 13, (2009/06/27)

The present invention relates to compounds of formula I, processes for their production and their use as anti-inflammatory agents.

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