1152853-30-9

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-amino-1H-pyrazol-1-yl)-N-methylacetamide(SALTDATA: 1.74HCl 0.19H2O) is used as a potential pharmaceutical agent due to the presence of the pyrazole moiety, which is commonly found in various bioactive compounds. The N-methylacetamide group suggests a possible interaction with biological systems, indicating its potential for development into a drug with therapeutic effects.
The specific applications and reasons for its use in the pharmaceutical industry are not detailed in the provided materials, but the compound's structural features and salt form suggest it may be explored for its potential bioactivity and suitability in drug formulations. Further research would be required to determine the exact therapeutic applications and mechanisms of action.

Upstream product

• 39753-81-6 ethyl 2-(4-nitro-1H-pyrazol-1-yl)acetate 
• 1339619-68-9 N-methyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide 
• 6715-84-0 methyl 2-(4-nitro-1H-pyrazol-1-yl)acetate 

Downstream Products

• 1420892-67-6 C₁₈H₂₀ClN₇O₂ 

Relevant academic research and scientific papers

INHIBITORS OF NECROPTOSIS

This invention relates to compounds of Formula (I) and salts, solvates, prodrugs, tautomers, N-oxides, stereoisomers, polymorphs and physiologically functional derivatives thereof. Also disclosed are methods of use of Formula (I), including in the inhibition of necroptosis and treatment of associated diseases, conditions and/or disorders.

ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS

Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).

Substitutive phenyl pyrimidine derivative as JAK kinase inhibitor or medicinal salt, preparation method and application thereof

The invention discloses a substitutive phenyl pyrimidine derivative as shown in a formula (I) as a JAK kinase inhibitor or medicinal salt, a preparation method and application thereof. The compound has excellent JAK inhibiting action and is used for preparing a drug for preventing, treating or improving autoimmune disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus and the like. The high activity JAK-3 inhibiting action IC50 shown by the compound can reach 1.7 n. The substitutive phenyl pyrimidine derivative is simple in synthetic route and high in implementation.

HETEROCYCLYL PYRIMIDINE ANALOGUES AS JAK INHIBITORS

The present invention relates to compounds of formula (I), wherein X1 to X5, Z1 to Z3, Y0, RY1, RY2 and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically- mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS

The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.