1339619-68-9

Upstream product

• 2075-46-9 4-nitro-1H-pyrazole 
• 96-30-0 chloroacetylmethylamide 
• 39753-81-6 ethyl 2-(4-nitro-1H-pyrazol-1-yl)acetate 
• 74-89-5 methylamine 
• 6715-84-0 methyl 2-(4-nitro-1H-pyrazol-1-yl)acetate 

Downstream Products

• 1152853-30-9 2-(4-amino-1H-pyrazol-1-yl)-N-methylacetamide 
• 1420892-67-6 C₁₈H₂₀ClN₇O₂ 

Relevant academic research and scientific papers

ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS

Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).

INHIBITORS OF NECROPTOSIS

This invention relates to compounds of Formula (I) and salts, solvates, prodrugs, tautomers, N-oxides, stereoisomers, polymorphs and physiologically functional derivatives thereof. Also disclosed are methods of use of Formula (I), including in the inhibition of necroptosis and treatment of associated diseases, conditions and/or disorders.

HETEROCYCLYL PYRIMIDINE ANALOGUES AS JAK INHIBITORS

The present invention relates to compounds of formula (I), wherein X1 to X5, Z1 to Z3, Y0, RY1, RY2 and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically- mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.