1152945-26-0

Basic information

• Product Name: 4-(5-amino-3-methyl-1H-pyrazol-1-yl)benzonitrile
• Synonyms: 1152945-26-0;4-(5-amino-3-methyl-1H-pyrazol-1-yl)benzonitrile;4-(5-amino-3-methylpyrazol-1-yl)benzonitrile;SCHEMBL14353427;FT-0729983;F53263
• CAS NO: 1152945-26-0
• Molecular Weight: 198.227
• Mol File: 1152945-26-0.mol

Chemical Properties

• CAS DataBase Reference: 4-(5-amino-3-methyl-1H-pyrazol-1-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-amino-3-methyl-1H-pyrazol-1-yl)benzonitrile(1152945-26-0)
• EPA Substance Registry System: 4-(5-amino-3-methyl-1H-pyrazol-1-yl)benzonitrile(1152945-26-0)

Safety Data

• Hazardous Substances Data: 1152945-26-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
4-(5-amino-3-methyl-1H-pyrazol-1-yl)benzonitrile is used as a building block for the synthesis of biologically active molecules, contributing to the development of new drugs and agrochemicals.
Used in Drug Development:
4-(5-amino-3-methyl-1H-pyrazol-1-yl)benzonitrile is utilized in the development of new drugs, thanks to its valuable intermediate properties in the production of pharmaceuticals and other organic compounds.
Used in Agrochemical Development:
4-(5-amino-3-methyl-1H-pyrazol-1-yl)benzonitrile is also used in the development of agrochemicals, indicating its broad application potential in different industries.
Used in Medicinal Chemistry:
The presence of amino and nitrile groups makes this compound instrumental in studying molecular pathways and mechanisms in the field of medicinal chemistry, aiding in understanding complex biological processes.

Upstream product

• 1118-61-2 3-Aminocrotononitrile 
• 17672-27-4 4-hydrazinobenzonitrile 

Downstream Products

• 1586005-02-8 4-(1-methyl-5-pentyl-6,7,8,9-tetrahydro-3H-pyrazolo[3,4-c]isoquinolin-3-yl)benzonitrile 
• 1586004-97-8 4-(5-butyl-1-methyl-7,8-dihydrocyclopenta[d]pyrazolo[3,4-b]pyridin-3(6H)-yl)benzonitrile 

Relevant articles and documents

Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4-b]quinoline Hybrid Heterocycles

The stereoselective syntheses of a library of novel spiro-tethered pyrazolo[3,4-b]quinoline-pyrrolidine/pyrrolothiazole/indolizine-oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo[3,4-b]quinoline derivatives.

Microwave synthesis of 1-aryl-1H-pyrazole-5-amines

A microwave-mediated synthesis of 1H-pyrazole-5-amines utilizing 1 M HCl at 150 °C was developed in order to provide products in a matter of minutes with minimal purification. Most reactions are complete in only 10 min and can be isolated via a simple filtration without the need for further purification by column chromatography or recrystallization. This method tolerates a range of functional groups and can be performed on milligram to gram scales.

NEW POSITIVE ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTOR

The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine alpha7 receptor.

PYRAZOLOPYRIDINES USEFUL IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM

The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said com- pounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine α7 receptor.